The role of oxidized phospholipids in COVID-19-associated hypercoagulopathy

Basit Öğe Kaydı
dc.authorscopusid14219156500
dc.authorscopusid55881189500
dc.authorscopusid57196589837
dc.authorscopusid57218879837
dc.authorscopusid6602163658
dc.authorscopusid6701664192
dc.contributor.authorAkpınar, Seval
dc.contributor.authorOran, Mustafa
dc.contributor.authorDoğan, Mustafa
dc.contributor.authorÇelikkol, Aliye
dc.contributor.authorErdem, İlknur
dc.contributor.authorTurgut, Burhan
dc.date.accessioned2022-05-11T14:02:44Z
dc.date.available2022-05-11T14:02:44Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractOBJECTIVE: There is more pronounced hypercoagulation in COVID-19 infection than in other viral lung infections. Oxidized phospholipids (OxPLs) appear in COVID-19-infected lungs due to oxidative stress, after which they promote the induction of tissue factor (TF) expression and inflammatory programmers in monocytes, as well as activate endothelial cells to recruit and bind to monocytes. Therefore, we aimed to demonstrate the role of OxPLs in inflammatory and procoagulant responses in COVID-19 infection. PATIENTS AND METHODS: Patients with a positive SARS-CoV-2 polymerase chain reaction test and ten healthy donors were included in the study. Peripheral blood was drawn at inclusion for OxPAPC, IFN-?, and CCL2 serum level measurements. Clinical data were collected from electronic patient medical files. The serum levels of OxPAPC, IFN?, and CCL2 were measured by immune assays. RESULTS: Seventy-two patients were included in the study. OxPAPC and CCL2 were higher in the patients than in the controls (<0.003 and 0.011, respectively). INF-? did not significantly differ between groups. There was no difference between the patients with lung involvement and those without CCL2, INF-?, and OxPAPC. D-dimer, CRP, and ferritin were higher in the patients with lung involvement. Serum levels of INF-? and CCL2 were positively correlated with each other (r:0.757, p<0.0001), but no correlation was detected between OxPAPC and INF-? or CCL2. There was no correlation between OxPAPC and hematologic or biochemical parameters. CONCLUSIONS: OxPAPC, which is thought to contribute to hypercoagulability, was found to be high in the patients with Covid-19 infection. The role of OxPLs in COVID-19-associated hypercoagulopathy should be investigated further in experimental models and in larger patient groups. © 2021 Verduci Editore s.r.l. All rights reserved.
dc.identifier.doi10.26355/eurrev_202108_26551
dc.identifier.endpage5309
dc.identifier.issn1128-3602
dc.identifier.issue16en_US
dc.identifier.pmid34486706
dc.identifier.scopus2-s2.0-85113919739
dc.identifier.scopusqualityQ2
dc.identifier.startpage5304
dc.identifier.urihttps://doi.org/10.26355/eurrev_202108_26551
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4456
dc.identifier.volume25
dc.identifier.wosWOS:000695652700029
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAkpınar, Seval
dc.institutionauthorOran, Mustafa
dc.institutionauthorDoğan, Mustafa
dc.institutionauthorÇelikkol, Aliye
dc.institutionauthorErdem, İlknur
dc.institutionauthorTurgut, Burhan
dc.language.isoen
dc.publisherVerduci Editore s.r.l
dc.relation.ispartofEuropean Review for Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCOVID-19
dc.subjectLung
dc.subjectOxidative stress injury
dc.subjectThrombosis
dc.subject1 palmitoyl 2 arachidonoyl phosphatidylcholine
dc.subjectC reactive protein
dc.subjectD dimer
dc.subjectferritin
dc.subjectgamma interferon
dc.subjectmonocyte chemotactic protein 1
dc.subjectphosphatidylcholine
dc.subjectphospholipid
dc.subjectunclassified drug
dc.subjectphospholipid
dc.subjectadult
dc.subjectaged
dc.subjectArticle
dc.subjectbiochemical analysis
dc.subjectblood sampling
dc.subjectcontrolled study
dc.subjectCOVID-19-associated coagulopathy
dc.subjectfemale
dc.subjecthematological parameters
dc.subjecthuman
dc.subjectimmunoassay
dc.subjectlipid metabolism
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectpolymerase chain reaction
dc.subjectprotein blood level
dc.subjectSevere acute respiratory syndrome coronavirus 2
dc.subjectadolescent
dc.subjectblood
dc.subjectblood clotting
dc.subjectisolation and purification
dc.subjectmiddle aged
dc.subjectoxidation reduction reaction
dc.subjectoxidative stress
dc.subjectvery elderly
dc.subjectyoung adult
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectBlood Coagulation
dc.subjectCOVID-19
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectOxidation-Reduction
dc.subjectOxidative Stress
dc.subjectPhospholipids
dc.subjectSARS-CoV-2
dc.subjectYoung Adult
dc.titleThe role of oxidized phospholipids in COVID-19-associated hypercoagulopathy
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
4456.pdf
Boyut:
457.91 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Tıp Fakültesi Koleksiyonu