Comparison of Topical Treatment with Silver Sulfadiazine and Sweetgum Oil (Liquidambar orientalis) on Burn Wound Healing in an Experimental Rat Model

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dc.authorid0000-0002-2270-2965
dc.authorscopusid25932306600
dc.authorscopusid26434076100
dc.authorscopusid24436194200
dc.authorscopusid17433815200
dc.authorscopusid55543809500
dc.authorscopusid55515412500
dc.authorscopusid7102765266
dc.authorwosidUYGUR, EMİNE/AAC-4470-2020
dc.authorwosidAktas, Cevat/D-8468-2011
dc.authorwosidsener, umit/AAZ-7728-2020
dc.authorwosidYilmaz, Ahsen/ABB-1083-2021
dc.contributor.authorYanık, Mehmet Emin
dc.contributor.authorUygur, Ramazan
dc.contributor.authorAktaş, Cevat
dc.contributor.authorEmir, Seyfi
dc.contributor.authorKumral, Bahadır
dc.contributor.authorŞener, Ümit
dc.contributor.authorKulaç, Mustafa
dc.contributor.authorErboğa, Mustafa
dc.contributor.authorUygur, Emine
dc.contributor.authorAydın, Murat
dc.contributor.authorYılmaz, Ahsen
dc.contributor.authorOrhan, Abdullah Erkan
dc.date.accessioned2022-05-11T14:07:33Z
dc.date.available2022-05-11T14:07:33Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Deri ve Zührevi Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Anatomi Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractOBJECTIVE: To investigate effects of Sweetgum oil (SO) on wound healing in comparison with silver sulfadiazine (SS) in a burn wound model, which was experimentally created on rats. It was observed in the literature that no study had investigated the effects of SO on burn wounds. STUDY DESIGN: Seventy-two Sprague Dawley rats were divided into 3 main groups: Burn, Burn+SS, and Burn+SO (subgroups: 4, 8, and 12 days). RESULTS: In the histopathological examinations it was observed that parameters indicating wound-healing stages had increased in the Burn+SS and Burn+SO groups more than in the Burn group, whereas they were similar in the Burn+SS and Burn+SO groups. In the PCNA immunostaining, more rapid epidermal growth, more increased thickening in the cuticular layer, and more prominent wound healing were observed in the Burn+SS and Burn+SO groups than in the Burn group. While hydroxyproline levels in the Burn+SS and Burn+SO subgroups were similar on Days 8 and 12, it was observed that levels were increased in the burn subgroups. CONCLUSION: Topical use of SO on burn wound areas had favorable effects on healing, indicating that this agent could be used as an alternative treatment for burn wounds.
dc.description.sponsorshipNamik Kemal University Research Center, Tekirdag, TurkeyNamik Kemal University [NKUBAP.00.20.AR.14.10]
dc.description.sponsorshipSupported under Project NKUBAP.00.20.AR.14.10 by the Namik Kemal University Research Center, Tekirdag, Turkey.
dc.identifier.endpage174
dc.identifier.issn0884-6812
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84975466466
dc.identifier.scopusqualityN/A
dc.identifier.startpage168
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5140
dc.identifier.volume38
dc.identifier.wosWOS:000399656100004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorYanık, Mehmet Emin
dc.institutionauthorUygur, Ramazan
dc.institutionauthorAktaş, Cevat
dc.institutionauthorEmir, Seyfi
dc.institutionauthorKumral, Bahadır
dc.institutionauthorŞener, Ümit
dc.institutionauthorKulaç, Mustafa
dc.institutionauthorErboğa, Mustafa
dc.institutionauthorUygur, Emine
dc.institutionauthorAydın, Murat
dc.institutionauthorYılmaz, Ahsen
dc.institutionauthorOrhan, Abdullah Erkan
dc.language.isoen
dc.publisherSci Printers & Publ Inc
dc.relation.ispartofAnalytical and Quantitative Cytopathology and Histopathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectburns
dc.subjectdermatologic agents
dc.subjecthydroxyproline
dc.subjectLiquidambar
dc.subjectPCNA
dc.subjectproliferating cell nuclear antigen
dc.subjectrats
dc.subjectlaboratory
dc.subjectsilver sulfadiazine
dc.subjectsweetgum
dc.subjectsweetgum oil
dc.subjecttopical antiinfective agents
dc.subjectwounds and injuries
dc.subjectHydroxyproline
dc.subjectTurkish
dc.subjectStyrax
dc.titleComparison of Topical Treatment with Silver Sulfadiazine and Sweetgum Oil (Liquidambar orientalis) on Burn Wound Healing in an Experimental Rat Model
dc.typeArticle

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