A comparison of clinical characteristics and course predictors in early- and childhood-onset schizophrenia

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dc.authoridHangul, Zehra/0000-0001-8397-5636
dc.authoridOnal, Bedia Sultan/0000-0003-2818-4764
dc.authoridSahin, Berkan/0000-0003-4699-3418
dc.authoridBozkurt, abdullah/0000-0002-8359-6131
dc.authoridAYAYDIN, Hamza/0000-0003-4909-0070
dc.authoridCobanoglu Osmanli, Cansu/0000-0002-9631-1262
dc.contributor.authorBaykal, Saliha
dc.contributor.authorBozkurt, Abdullah
dc.contributor.authorcobanoglu Osmanli, Cansu
dc.contributor.authorOnal, Bedia Sultan
dc.contributor.authorSahin, Berkan
dc.contributor.authorKaradogan, Zeynep Nur
dc.contributor.authorKaradag, Mehmet
dc.date.accessioned2024-10-29T17:58:44Z
dc.date.available2024-10-29T17:58:44Z
dc.date.issued2024
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractAimThe aim of this study was to compare the clinical characteristics of childhood-onset schizophrenia (COS) and early-onset schizophrenia (EOS) during the first- episode psychosis and the stable period, to examine psychopharmacological treatment approaches, and to investigate potential predictive factors for prognosis.MethodsDemographic, clinical, and psychopharmacological therapy data for 31 patients diagnosed with COS and 66 with EOS were retrieved from the file records in this multicenter study. Symptom distribution and disease severity and course were evaluated twice, in the acute psychotic stage and in the latest stable phase, during follow-up using the positive and negative syndrome scale (PANSS) and clinical global impression (CGI) scales.ResultsA statistically significant difference was observed between the groups' CGI improvement rates and median last stable stage PANSS positive, negative, and general psychopathology symptom scores (p = .005, p = .031, p = .005, and p = .012, respectively). Premorbid neurodevelopmental disorder and obsessive-compulsive disorder and comorbidities were more common in the COS group (p = .025 and p = .030, respectively), and treatment required greater multiple antipsychotic use in that group (p = .013). When the independent variables affecting the difference between pre- and post-treatment PANSS scores were examined using linear regression analysis, the model established was found to be statistically significant (F = 5.393; p = .001), and the group variable (p = .024), initial disease severity (p = .001), and socioeconomic level (p = .022; p = .007) emerged as predictive factors for the disease course.ConclusionAlthough early diagnosis and treatment is an important factor in improving prognosis in schizophrenia, more specific predictors for schizophrenia need to be identified. Additionally, preventive programs and pharmacological methods need to be developed in children with neurodevelopmental problems, particularly those from low socioeconomic status families.
dc.description.sponsorshipThe authors thank the patients and their families who participated in the study.
dc.identifier.doi10.1111/eip.13594
dc.identifier.issn1751-7885
dc.identifier.issn1751-7893
dc.identifier.pmid38992332
dc.identifier.scopus2-s2.0-85198378306
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1111/eip.13594
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14477
dc.identifier.wosWOS:001268909300001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofEarly Intervention in Psychiatry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectchildhood onset schizophrenia
dc.subjectclinical features
dc.subjectcomorbidities
dc.subjectearly onset schizophrenia
dc.subjectpatient outcome assessment
dc.subjectpsychopharmacology
dc.titleA comparison of clinical characteristics and course predictors in early- and childhood-onset schizophrenia
dc.typeArticle

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