Protective effects of melatonin against arsenic-induced apoptosis and oxidative stress in rat testes

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dc.authorscopusid26434076100
dc.authorscopusid24436194200
dc.authorscopusid25647609500
dc.authorscopusid55558318400
dc.authorscopusid7006831777
dc.authorscopusid6603048599
dc.authorwosidUYGUR, EMİNE/AAC-4470-2020
dc.authorwosidAktas, Cevat/D-8468-2011
dc.contributor.authorUygur, Ramazan
dc.contributor.authorAktaş, Cevat
dc.contributor.authorÇağlar, Veli
dc.contributor.authorUygur, Emine
dc.contributor.authorErdoğan, Hasan
dc.contributor.authorÖzen, Oğuz Aslan
dc.date.accessioned2022-05-11T14:09:56Z
dc.date.available2022-05-11T14:09:56Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Anatomi Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.departmentMeslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Terapi ve Rehabilitasyon Bölümü
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.description.abstractThis study aimed to investigate the protective effects of melatonin against arsenic-induced apoptosis and oxidative stress in rat testes. A total of 27 male rats were divided into 3 groups: control (saline: 5 ml kg(-1) day(-1), intragastrically), arsenic (sodium arsenite (NaAsO2): 5 mg kg(-1) day(-1), intragastrically), and arsenic + melatonin (sodium arsenite (NaAsO2): 5 mg kg(-1) day(-1), intragastrically and melatonin: 25 mg kg(-1) day(-1), intraperitoneally) group. At the end of 30 days, the rats were killed under anesthesia. Histopathological examination showed that testicular injury mediated by arsenic was ameliorated by the administration of melatonin. The number of apoptotic germ cell was increased, and the number of proliferating cell nuclear antigen (PCNA)-positive germ cell was decreased in testis after arsenic administration. Our data indicate a significant reduction in the activity of terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling, and there was a rise in the expression of PCNA in testis of arsenic + melatonin group. The decreased superoxide dismutase, catalase, and glutathione peroxidase activities as well as increased malondialdehyde levels in testis due to arsenic administration were also counteracted by melatonin. These data suggested that melatonin has beneficial effects against arsenic-induced testicular damage by decreasing morphological damage, germ cell apoptosis, lipid peroxidation, and oxidative stress. Our results suggest that melatonin plays a protective role against arsenic-induced testicular apoptosis and oxidative stress.
dc.description.sponsorshipNamik Kemal University Scientific Research Projects UnitNamik Kemal University [NKUBAP.00.20.AR.12.07]
dc.description.sponsorshipThis study was supported by Namik Kemal University Scientific Research Projects Unit (Project Number: NKUBAP.00.20.AR.12.07).
dc.identifier.doi10.1177/0748233713512891
dc.identifier.endpage859
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue5en_US
dc.identifier.pmid24318767
dc.identifier.scopus2-s2.0-84968764956
dc.identifier.scopusqualityQ3
dc.identifier.startpage848
dc.identifier.urihttps://doi.org/10.1177/0748233713512891
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5205
dc.identifier.volume32
dc.identifier.wosWOS:000375578200010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorUygur, Ramazan
dc.institutionauthorAktaş, Cevat
dc.institutionauthorÇağlar, Veli
dc.institutionauthorUygur, Emine
dc.institutionauthorErdoğan, Hasan
dc.institutionauthorÖzen, Oğuz Aslan
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.ispartofToxicology and Industrial Health
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectArsenic
dc.subjectmelatonin
dc.subjecttestis
dc.subjectapoptosis
dc.subjectoxidative stress
dc.subjectGerm-Cell Apoptosis
dc.subjectSodium Arsenite
dc.subjectLipid-Peroxidation
dc.subjectSuperoxide-Dismutase
dc.subjectTesticular Damage
dc.subjectAscorbic-Acid
dc.subjectMice
dc.subjectToxicity
dc.subjectSpermatogenesis
dc.subjectNeurotoxicity
dc.titleProtective effects of melatonin against arsenic-induced apoptosis and oxidative stress in rat testes
dc.typeArticle

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