Histopathological Evaluation of the Anterior Cruciate Ligament in Patients With Advanced Gonarthrosis

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dc.contributor.authorPolat, Elif
dc.contributor.authorGunaydin, Burak
dc.contributor.authorKarabag, Sevil
dc.contributor.authorHeybeli, Nurettin
dc.date.accessioned2025-04-06T12:23:47Z
dc.date.available2025-04-06T12:23:47Z
dc.date.issued2025
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractIntroduction: Knee osteoarthritis is a degenerative disease of the knee joint that leads to progressive loss of articular cartilage. There is only limited information in the literature on the degeneration of the anterior cruciate ligament (ACL) in patients with gonarthrosis. In this study, ACL samples excised during the surgery of patients undergoing total knee replacement (TKR) in 2019-2020 were evaluated histopathologically. The present study aims to investigate the relationship between the degeneration of the ACL and the stage of gonarthrosis. Methods: Direct X-rays of 47 patients undergoing knee arthroplasty were evaluated and stratified into two groups: Stage 3 (Group 1) and Stage 4 (Group 2). ACL samples were examined histopathologically. Staining was performed with hematoxylin-eosin (H&E), Alcian blue, and Masson's trichrome. The degree of degeneration was determined according to the Movin score and Bonar score. Based on these scores, the statistical significance of the relationship between the stage of gonarthrosis and histopathological examination results was evaluated. Results: When Group 1 patients were graded according to total Movin scores, the result was mild degeneration in 72.7% of the patients, while the corresponding rates were 76% in Group 2. None of the patients had a score reflecting severe degeneration. The total Bonar scores showed mild degeneration in 68.2% of Group 1 patients. In Group 2, the scores showed mild degeneration in 52% of the patients. No statistically significant difference was found between the groups in either scoring. Conclusion: It was determined that comparable degeneration occurred in the ACL with the progression of the stage of gonarthrosis.
dc.identifier.doi10.1111/1756-185X.70160
dc.identifier.issn1756-1841
dc.identifier.issn1756-185X
dc.identifier.issue3
dc.identifier.pmid40040537
dc.identifier.scopus2-s2.0-86000040006
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1111/1756-185X.70160
dc.identifier.urihttps://hdl.handle.net/20.500.11776/17187
dc.identifier.volume28
dc.identifier.wosWOS:001437941800001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofInternational Journal of Rheumatic Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250406
dc.subjectanterior cruciate ligament
dc.subjectcollagen
dc.subjectdegeneration
dc.subjectgonarthrosis
dc.subjecthistopathology
dc.titleHistopathological Evaluation of the Anterior Cruciate Ligament in Patients With Advanced Gonarthrosis
dc.typeArticle

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