External Validation of the GREAT Score in Turkish Patients with Graves' Hyperthyroidism Treated with the Titration Regimen Method of Antithyroid Drugs: A Multicenter Study

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dc.authorid0000-0002-0920-6895
dc.authorid0000-0001-8084-848X
dc.authorid0000-0002-8329-140X
dc.authorscopusid36656843500
dc.authorscopusid35271464000
dc.authorscopusid11339331700
dc.authorscopusid6602975843
dc.authorscopusid57147304700
dc.authorscopusid57208882907
dc.authorscopusid55356053700
dc.authorwosidfaruk, kilinc/W-7108-2018
dc.authorwosidElbuken, Gulsah/ABD-5689-2020
dc.authorwosidKadioglu, Pinar/AAM-9935-2020
dc.authorwosidZuhur, Sayid/AAC-6839-2020
dc.authorwosidSahin, Serdar/AAN-1047-2020
dc.contributor.authorZuhur, Sayid Shafi
dc.contributor.authorElbüken, Gülşah
dc.contributor.authorYıldız, İsmail
dc.contributor.authorKadıoğlu, Pınar
dc.contributor.authorErol, Selvinaz
dc.contributor.authorŞahin, Serdar
dc.contributor.authorAltuntaş, Yüksel
dc.date.accessioned2022-05-11T14:13:59Z
dc.date.available2022-05-11T14:13:59Z
dc.date.issued2019
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.description.abstractRecently, the Graves & apos; Recurrent Events After Therapy score (GREAT) was proposed as a useful tool to predict relapse before starting antithyroid drugs (ATD) in patients with Graves & apos; disease (GD). Therefore, we intended to assess the validity of the GREAT score in Turkish patients with GD, including patients who experienced a poorly controlled disease (multiple episodes of hyperthyroidism followed by euthyroidism or rarely hypothyroidism) during ATD dose titration. This is a retrospective multicenter study including 517 patients with the first episode of GD who were treated for at least 12 months. The patients were classified as relapse+poorly controlled disease (non-remission) and remission groups. During a median follow-up time of 35 months (12-144 months), 191 (37%) patients experienced a relapse, 136 (26.3%) a poorly controlled disease, and 190 (36.7%) remained in remission. Patients with non-remission disease tended to have significantly higher serum levels of TRAb, fT4, and fT3, and have larger goiter sizes on palpation at baseline, as compared with the remission group. Non-remission disease occurred in 12, 35, and, 53% of the patients falling into GREAT class I, II, and III, respectively (hazard ratio 2.56, 95% CI 2.02-3.51, p=0.012, and hazard ratio 3.54, 95% CI 2.12-5.91, p<0.001, for GREAT class II and III against class I, respectively). According to our study, the GREAT score is a useful tool to predict the risk of relapse as well as the occurrence of poorly controlled disease before starting treatment with ATDs.
dc.identifier.doi10.1055/a-0974-3991
dc.identifier.endpage633
dc.identifier.issn0018-5043
dc.identifier.issn1439-4286
dc.identifier.issue10en_US
dc.identifier.pmid31499558
dc.identifier.scopus2-s2.0-85072904372
dc.identifier.scopusqualityQ2
dc.identifier.startpage627
dc.identifier.urihttps://doi.org/10.1055/a-0974-3991
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5732
dc.identifier.volume51
dc.identifier.wosWOS:000488472400001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorZuhur, Sayid Shafi
dc.institutionauthorYıldız, İsmail
dc.institutionauthorElbüken, Gülşah
dc.institutionauthorTopçu, Birol
dc.language.isoen
dc.publisherGeorg Thieme Verlag Kg
dc.relation.ispartofHormone and Metabolic Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGraves' disease
dc.subjectrelapse
dc.subjectantithyroid drugs
dc.subjectGREAT score
dc.subjectPredict Relapse
dc.subjectDisease
dc.subjectTherapy
dc.subjectRisk
dc.subjectManagement
dc.subjectRecurrence
dc.subjectRemission
dc.titleExternal Validation of the GREAT Score in Turkish Patients with Graves' Hyperthyroidism Treated with the Titration Regimen Method of Antithyroid Drugs: A Multicenter Study
dc.typeArticle

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