Acute phase response and oxidative stress status in familial Mediterranean fever (FMF)

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dc.authorid0000-0001-6625-1652
dc.authorid0000-0002-5292-3574
dc.authorscopusid23968920100
dc.authorscopusid6506285184
dc.authorscopusid7003445991
dc.authorscopusid16506468900
dc.authorscopusid16506392100
dc.authorscopusid42661653300
dc.authorscopusid7003777660
dc.authorwosidBOLAYIRLI, Murat/D-4769-2019
dc.authorwosidAndican, Zeynep Gülnur/C-8079-2019
dc.authorwosidHamuryudan, Vedat/AAA-1100-2020
dc.contributor.authorGüzel, Savaş
dc.contributor.authorAndican, Gülnur
dc.contributor.authorSeven, Arzu
dc.contributor.authorAslan, Mahmure
dc.contributor.authorBolayırlı, Murat
dc.contributor.authorGüzel, Eda Çelik
dc.contributor.authorHamuryudan, Vedat
dc.date.accessioned2022-05-11T14:12:33Z
dc.date.available2022-05-11T14:12:33Z
dc.date.issued2012
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Aile Hekimliği Ana Bilim Dalı
dc.description.abstractWe aimed to determine acute phase response (APR) and oxidative stress in patients with familial Mediterranean fever (FMF) and compare these characteristics with those in healthy controls; 20 patients with FMF and 15 healthy controls were enrolled in the study. The erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP), fibrinogen, and leukocyte levels were determined as markers of APR. Thiobarbituric acid reactive substances (TBARS), conjugated diene, and lipid hydroperoxide levels were measured as markers of lipid peroxidation. Carbonyl group and thiol (T-SH) levels were analyzed to determine the oxidative damage to proteins, and 8-hydroxy-2-deoxyguanosine (8-OHdG) was measured to reflect DNA oxidation. The erythrocyte glutathione (GSH) level, and glutathione peroxidase (GSH-Px), CuZn superoxide dismutase (CuZn SOD), and catalase activities were measured as markers of antioxidant status. Conjugated diene (p < 0.001) and carbonyl group (p < 0.05) levels were significantly higher and GSH-Px activity (p < 0.01) was significantly lower in FMF patients compared with controls. FMF patients in the attack period (n = 8) had significantly higher CRP, ESR, fibrinogen, and leukocyte levels (p < 0.001) than patients in the attack-free period (n = 12). The T-SH level (p < 0.05) was significantly higher and CuZn SOD activity was significantly lower (p < 0.05) in FMF patients in the attack period. The findings revealed upregulated APR during the attack period in FMF patients and enhanced oxidative stress in the FMF patients as compared to controls.
dc.description.sponsorshipIstanbul University Research Foundation, TurkeyIstanbul University
dc.description.sponsorshipThis study was supported by Istanbul University Research Foundation, Turkey.
dc.identifier.doi10.1007/s10165-011-0517-5
dc.identifier.endpage437
dc.identifier.issn1439-7595
dc.identifier.issn1439-7609
dc.identifier.issue3en_US
dc.identifier.pmid21947799
dc.identifier.scopus2-s2.0-84865353583
dc.identifier.scopusqualityQ2
dc.identifier.startpage431
dc.identifier.urihttps://doi.org/10.1007/s10165-011-0517-5
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5598
dc.identifier.volume22
dc.identifier.wosWOS:000305275300015
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGüzel, Eda Çelik
dc.institutionauthorÇelikkol, Aliye
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofModern Rheumatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectFamilial Mediterranean fever
dc.subjectAcute phase response
dc.subjectOxidative stress
dc.subjectAntioxidant status
dc.subjectDna-Damage
dc.subjectSerum
dc.subjectInflammation
dc.titleAcute phase response and oxidative stress status in familial Mediterranean fever (FMF)
dc.typeArticle

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