Hyperbaric oxygen treatment ameliorates lung injury in paraquat intoxicated rats

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dc.authorid0000-0003-4720-1945
dc.authorid0000-0001-5549-3883
dc.authorid0000-0002-1503-329X
dc.authorid0000-0003-3819-6822
dc.authorid0000-0001-5573-4923
dc.authorscopusid35764299300
dc.authorscopusid55876970900
dc.authorscopusid55939598700
dc.authorscopusid56511741900
dc.authorscopusid57060622600
dc.authorscopusid23391660500
dc.authorscopusid56895970700
dc.authorwosidAKCILAR, Raziye/A-5351-2018
dc.authorwosidKocak, Emel Fatma/F-6055-2011
dc.authorwosidYumun, Gunduz/J-5643-2013
dc.contributor.authorAkçılar, Raziye
dc.contributor.authorAkçılar, Aydın
dc.contributor.authorŞimşek, Hasan
dc.contributor.authorKoçak, Fatma Emel
dc.contributor.authorKoçak, Cengiz
dc.contributor.authorYümün, Gündüz
dc.contributor.authorBayat, Zeynep
dc.date.accessioned2022-05-11T14:35:59Z
dc.date.available2022-05-11T14:35:59Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kalp ve Damar Cerrahisi Ana Bilim Dalı
dc.description.abstractParaquat (PQ) is an agrochemical agent commonly used worldwide, which can cause acute lung injury (ALI) and death. Hyperbaric oxygen treatment (HBOT) is a therapeutic method, but the mechanisms of the protective effect of HBOT on ALI remain elusive. The purpose of this study was to evaluate the effect of HBOT on acute lung injury induced by PQ in rats. Wistar Albino rats (n=21) were separated into three groups of seven animals each: control (C), PQ, and PQ + HBOT groups. 20 mg/kg PQ was administered intraperitoneally in PQ and PQ + HBOT groups to induce experimental lung injury. Three days after PQ treatment, PQ + HBOT group was administered 100% O-2 at 2.0 ATA for 1 hour per day, for five consecutive days. At the end of the study, lung tissue was obtained for determining total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI) and histopathological determination. Tumor necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6), basic fibroblast growth factor (bFGF), transforming growth factor (TGF)-beta 1 mRNA levels were assessed by quantitative reverse transcription-polymerase chain reaction. In addition, the inducible nitric oxide synthase (iNOS) level in the plasma was determined. Plasma iNOS, OSI, tissue TNF-alpha, TGF-beta 1 and bFGF mRNA levels, and histological injury scores in PQ + HBOT group were significantly lower than PQ group. TAS level in PQ + HBOT group was significantly higher than PQ group. The findings suggest that HBOT could effectively ameliorate PQ-induced lung injury in rats.
dc.identifier.endpage13042
dc.identifier.issn1936-2625
dc.identifier.issue10en_US
dc.identifier.pmid26722498
dc.identifier.scopus2-s2.0-85013421311
dc.identifier.scopusqualityN/A
dc.identifier.startpage13034
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8324
dc.identifier.volume8
dc.identifier.wosWOS:000367814200118
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYümün, Gündüz
dc.language.isoen
dc.publisherE-Century Publishing Corp
dc.relation.ispartofInternational Journal of Clinical and Experimental Pathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectParaquat
dc.subjectlung injury
dc.subjecthyperbaric oxygen treatment
dc.subjectoxidant
dc.subjectantioxidant
dc.subjectFibroblast-Growth-Factor
dc.subjectTransforming Growth-Factor-Beta-1
dc.subjectOxidative Stress
dc.subjectNitric-Oxide
dc.subjectExpression
dc.subjectTherapy
dc.subjectFibrosis
dc.subjectOzone
dc.subjectTumor
dc.titleHyperbaric oxygen treatment ameliorates lung injury in paraquat intoxicated rats
dc.typeArticle

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