Effect of Direct-acting Oral Anticoagulants and Warfarin on Hospital Outcomes in Upper Gastrointestinal Bleeding

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dc.authorscopusid55572782100
dc.authorscopusid56004154000
dc.authorscopusid6602835899
dc.authorscopusid42960912700
dc.authorscopusid36608599700
dc.contributor.authorSolakoğlu, Tevfik
dc.contributor.authorKöseoğlu, Hüseyin
dc.contributor.authorKüçükmetin, Nurten Türkel
dc.contributor.authorAkar, Mustafa
dc.contributor.authorMete, Rafet
dc.date.accessioned2023-04-20T08:04:17Z
dc.date.available2023-04-20T08:04:17Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractObjective: To evaluate the comparison of direct-acting oral anticoagulants (DOACs) and warfarin for their effects on major bleeding and hospital outcomes in patients with acute nonvariceal upper gastrointestinal bleeding (NVUGIB). Study Design: An observational study. Place and Duration of Study: Tekirdag Namik Kemal University Hospital, Hitit University Erol Olçok Education and Research Hospital, between January and December 2021. Methodology: Adult patients prescribed warfarin and DOACs were followed up for one year. Their length of hospital stay, need for intensive care unit admission, need for red blood cell transfusion, and major bleeding rates were compared. Results: Thirty-two patients (61.5%) were user of DOACs (DOAC group), and 20 patients (38.5%) were users of warfarin (warfarin group). No statistically significant difference was determined between patients in warfarin group and DOAC group for the number of packed red blood cells transfused [median 3 (0-6) units, 3 (0-10) units, p=0.229, respectively], length of hospital stay [median 5 days (3-10), and 4.5 days (2-20), p=0.739, respectively], rate of intensive care unit admission [(n=9, 45%; and n=10 (31%), p=0.623, respectively] and the occurrence of major bleeding events (warfarin-70%; DOACs-78%; p=0.529). Conclusion: Major bleeding episodes and hospital outcomes of acute NVUGIB were similar between patients receiving warfarin and DOACs. © 2022 College of Physicians and Surgeons Pakistan. All rights reserved.
dc.identifier.doi10.29271/jcpsp.2022.10.1266
dc.identifier.endpage1271
dc.identifier.issn1022-386X
dc.identifier.issue10en_US
dc.identifier.pmid36205269
dc.identifier.scopus2-s2.0-85139324604
dc.identifier.scopusqualityQ3
dc.identifier.startpage1266
dc.identifier.urihttps://doi.org/10.29271/jcpsp.2022.10.1266
dc.identifier.urihttps://hdl.handle.net/20.500.11776/11073
dc.identifier.volume32
dc.identifier.wosWOS:000886033700007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSolakoğlu, Tevfik
dc.language.isoen
dc.publisherCollege of Physicians and Surgeons Pakistan
dc.relation.ispartofJournal of the College of Physicians and Surgeons Pakistan
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDirect-acting oral anticoagulants
dc.subjectGastrointestinal bleeding
dc.subjectMortality
dc.subjectOutcome
dc.subjectWarfarin
dc.subjectapixaban
dc.subjectdabigatran
dc.subjectedoxaban
dc.subjectproton pump inhibitor
dc.subjectrivaroxaban
dc.subjectwarfarin
dc.subjectanticoagulant agent
dc.subjectblood clotting factor 10a inhibitor
dc.subjectwarfarin
dc.subjectaged
dc.subjectArticle
dc.subjectCharlson Comorbidity Index
dc.subjectclinical outcome
dc.subjectcontinuous infusion
dc.subjectdrug effect
dc.subjecterythrocyte transfusion
dc.subjectfemale
dc.subjectfollow up
dc.subjecthuman
dc.subjectintensive care unit
dc.subjectlength of stay
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmoderate renal impairment
dc.subjectmulticenter study
dc.subjectobservational study
dc.subjectprescription
dc.subjectsevere renal impairment
dc.subjectupper gastrointestinal bleeding
dc.subjectadult
dc.subjectatrial fibrillation
dc.subjectgastrointestinal hemorrhage
dc.subjecthospital
dc.subjectoral drug administration
dc.subjectretrospective study
dc.subjectAdministration, Oral
dc.subjectAdult
dc.subjectAnticoagulants
dc.subjectAtrial Fibrillation
dc.subjectFactor Xa Inhibitors
dc.subjectGastrointestinal Hemorrhage
dc.subjectHospitals
dc.subjectHumans
dc.subjectRetrospective Studies
dc.subjectWarfarin
dc.titleEffect of Direct-acting Oral Anticoagulants and Warfarin on Hospital Outcomes in Upper Gastrointestinal Bleeding
dc.typeArticle

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