The effect of methylene blue treatment on aspiration pneumonia

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dc.authorid0000-0001-9103-4844
dc.authorscopusid7006356462
dc.authorscopusid37056003300
dc.authorscopusid8855945800
dc.authorscopusid6507986716
dc.authorscopusid16443917200
dc.authorscopusid36023238400
dc.authorscopusid7006498929
dc.authorwosidColak, Alkin/R-8739-2017
dc.contributor.authorKanter, Mehmet
dc.contributor.authorŞahin, Sevtap Hekimoglu
dc.contributor.authorBaşaran, Umit Nusret
dc.contributor.authorAyvaz, Süleyman
dc.contributor.authorAksu, Burhan
dc.contributor.authorErboğa, Mustafa
dc.contributor.authorÇolak, Alkın
dc.date.accessioned2022-05-11T14:41:28Z
dc.date.available2022-05-11T14:41:28Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractBackground: The study aimed to examine whether methylene blue (MB) prevents different pulmonary aspiration materials-induced lung injury in rats. Methods: The experiments were designed in 60 Sprague-Dawley rats, ranging in weight from 250-300 g, randomly allotted into one of six groups (n = 10): saline control, Biosorb Energy Plus (BIO), hydrochloric acid (HCl), saline + MB treated, BIO + MB treated, and HCl + MB treated. Saline, BIO, and HCl were injected into the lungs in a volume of 2 mL/kg. After surgical procedure, MB was administered intraperitoneally for 7 days at a daily dose of 2 mg/kg per day. Seven days later, rats were killed, and both lungs in all groups were examined biochemically and histopathologically. Results: Our findings show that MB inhibits the inflammatory response reducing significantly (P < 0.05) peribronchial inflammatory cell infiltration, alveolar septal infiltration, alveolar edema, alveolar exudate, alveolar histiocytes, interstitial fibrosis, granuloma, and necrosis formation in different pulmonary aspiration models. Pulmonary aspiration significantly increased the tissue hydroxyproline content, malondialdehyde levels, and decreased (P < 0.05) the antioxidant enzyme (superoxide dismutase and glutathione peroxidase) activities. MB treatment significantly (P < 0.05) decreased the elevated tissue hydroxyproline content and malondialdehyde levels and prevented the inhibition of superoxide dismutase and glutathione peroxidase (P < 0.05) enzymes in the tissues. Furthermore, there is a significant reduction in the activity of inducible nitric oxide synthase (iNOS), terminal deoxynucleotidyl transferase dUTP nick end labeling, and arise in the expression of surfactant protein D in lung tissue of different pulmonary aspiration models with MB therapy. Conclusions: MB treatment might be beneficial in lung injury and therefore shows potential for clinical use. (C) 2015 Elsevier Inc. All rights reserved.
dc.identifier.doi10.1016/j.jss.2014.08.039
dc.identifier.endpage919
dc.identifier.issn0022-4804
dc.identifier.issn1095-8673
dc.identifier.issue2en_US
dc.identifier.pmid25260956
dc.identifier.scopus2-s2.0-84916908884
dc.identifier.scopusqualityQ1
dc.identifier.startpage909
dc.identifier.urihttps://doi.org/10.1016/j.jss.2014.08.039
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9190
dc.identifier.volume193
dc.identifier.wosWOS:000346244300051
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorErboğa, Mustafa
dc.language.isoen
dc.publisherAcademic Press Inc Elsevier Science
dc.relation.ispartofJournal of Surgical Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectiNOS
dc.subjectMethylene blue
dc.subjectPulmonary aspiration
dc.subjectSurfactant protein D
dc.subjectTUNEL
dc.subjectRespiratory-Distress-Syndrome
dc.subjectInduced Lung Injury
dc.subjectNitric-Oxide Synthase
dc.subjectSurfactant Protein-D
dc.subjectDetecting Pulmonary Aspiration
dc.subjectAcid Aspiration
dc.subjectTracheobronchial Aspiration
dc.subjectReperfusion Injury
dc.subjectFeeding Aspiration
dc.subjectEnteral Solutions
dc.titleThe effect of methylene blue treatment on aspiration pneumonia
dc.typeArticle

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