Evaluation of in Vitro Activity of Fosfomycin and Other Antimicrobial Agents against Urinary Escherichia coli Isolates

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dc.authorid0000-0002-8711-7820
dc.authorscopusid55169371200
dc.authorscopusid6602366586
dc.authorscopusid56018499100
dc.authorscopusid57188868231
dc.contributor.authorUzun, Aslıhan
dc.contributor.authorGülen, Dumrul
dc.contributor.authorTanrıverdi, Yeliz
dc.contributor.authorKaya, Ayşe Demet
dc.date.accessioned2022-05-11T14:14:08Z
dc.date.available2022-05-11T14:14:08Z
dc.date.issued2012
dc.departmentYüksekokullar, Sağlık Yüksekokulu, Hemşirelik Bölümü
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalı
dc.description.abstractObjective: Fosfomycin is an antimicrobial agent commonly used in uncomplicated urinary tract infections. The objective of this study is to evaluate in vitro activity of fosfomycin against Escherichia coli strains isolated from urine specimens. Methods: Data were retrieved from two hospitals in Tekirdag, Turkey. We retrospectively examined the susceptibility results of E. coli strains collected over one year (January 2010-March 2011) to fosfomycin. Susceptibility of the isolates was determined by the disk diffusion method according to Clinical and Laboratory Standards Institute (CLSI) criteria. Results: A total of 561 E. coli strains were examined and 34 (6.1%) of the isolates were resistant to fosfomycin. Resistance was highest amongst isolates taken from outpatients (73.52%) and from the urology clinics (47.05%). In vitro activities of 561 isolates against other antimicrobial agents were also evaluated. Resistance rates of the strains against ampicillin-sulbactam, ciprofloxacin, levofloxacin, gentamicin, and amikacin were 44.8%, 19.4%, 18.1%, 15.1%, and 11.8%, respectively. Conclusions: According to data obtained from this study, fosfomycin seems to have good levels of in vitro activity against urinary E. coli isolates in our region. Further evaluation of its potential clinical effectiveness is needed in followup to these in vitro antimicrobial susceptibility results.
dc.identifier.doi10.5152/kd.2012.21
dc.identifier.endpage80
dc.identifier.issn1301-143X
dc.identifier.issn1309-1484
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84893156620
dc.identifier.scopusqualityQ4
dc.identifier.startpage77
dc.identifier.urihttps://doi.org/10.5152/kd.2012.21
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5796
dc.identifier.volume25
dc.identifier.wosWOS:000420928600007
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorGülen, Dumrul
dc.institutionauthorTanrıverdi, Yeliz
dc.institutionauthorKaya, Ayşe Demet
dc.language.isotr
dc.publisherDoc Design Informatics Co Ltd
dc.relation.ispartofKlimik Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectUrinary tract infections
dc.subjectEscherichia coli
dc.subjectfosfomycin
dc.subjectTract-Infections
dc.subjectResistance
dc.titleEvaluation of in Vitro Activity of Fosfomycin and Other Antimicrobial Agents against Urinary Escherichia coli Isolates
dc.title.alternativeFosfomisin ve bazi{dotless} antimikrobiyal ajanlari{dotless}n üriner escherichia coli i?zolatlari{dotless}na in vitro etkinli?inin de?erlendirilmesi]
dc.typeArticle

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