THE EFFECT OF QUERCETIN AND QUERCETIN-3-D-XYLOSIDE ON BREAST CANCER PROLIFERATION AND MIGRATION

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dc.contributor.authorYüksel, Tuğba Nurcan
dc.contributor.authorBozgeyik, Esra
dc.contributor.authorYayla, Muhammed
dc.date.accessioned2023-04-20T08:04:15Z
dc.date.available2023-04-20T08:04:15Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.description.abstractBackground and Purpose: The aim of this study is to investigate the migration, wound healing, colony formation, and cytotoxic effects of Quercetin-3-D-xyloside (reynoutrin), a quercetin derivative, in breast cancer cells Methods: In the present study, CRL-4010, MCF7 and MDA-MB-231 cells were used to evaluate the cytotoxic, antiproliferative and migration effects of reynoutrin on breast cancer. The IC50 concentration (400 mu g/ml) of reynoutrin, quercetin and cisplatin in the cells was determined. For cytotoxicity assessments, varying concentrations of quercetin, reynoutrin and cisplatin were applied and incubated 24h and 48h. In addition, to examine effects of reynoutrin on migration, cells were seeded in 6-well plates and incubated for 24 hours. For the colony formation assay cells were seeded to 12-well plates at a concentration of 1000 cells/well and incubated overnight. Results: These results indicated that reynoutrin markedly inhibit the cell viability in breast cancer. Conclusion: We have demonstrated for the first time with the present study that reynoutrin suppressed the progression of breast cancer cell proliferation induction and may provide a potential therapeutic target for breast cancer treatment. However, these results should be further confirmed by future more comprehensive studies.
dc.identifier.doi10.30621/jbachs.1056769
dc.identifier.endpage244
dc.identifier.issn2458-8938
dc.identifier.issn2564-7288
dc.identifier.issue2en_US
dc.identifier.startpage235
dc.identifier.urihttps://doi.org/10.30621/jbachs.1056769
dc.identifier.urihttps://hdl.handle.net/20.500.11776/11057
dc.identifier.volume6
dc.identifier.wosWOS:000809667400027
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.institutionauthorYüksel, Tuğba Nurcan
dc.language.isoen
dc.publisherDokuz Eylul Univ Inst Health Sciences
dc.relation.ispartofJournal of Basic and Clinical Health Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectReynoutrin
dc.subjectQuercetin
dc.subjectCytotoxicity
dc.subjectBreast Cancer
dc.subjectMigration
dc.subjectCell-Cycle Arrest
dc.subjectCisplatin Cytotoxicity
dc.subjectAntioxidant Activity
dc.subjectFlavonoids
dc.subjectApoptosis
dc.subjectStatistics
dc.subjectAutophagy
dc.subjectTherapy
dc.titleTHE EFFECT OF QUERCETIN AND QUERCETIN-3-D-XYLOSIDE ON BREAST CANCER PROLIFERATION AND MIGRATION
dc.typeArticle

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