THE EFFECT OF QUERCETIN AND QUERCETIN-3-D-XYLOSIDE ON BREAST CANCER PROLIFERATION AND MIGRATION
Yükleniyor...
Dosyalar
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Dokuz Eylul Univ Inst Health Sciences
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background and Purpose: The aim of this study is to investigate the migration, wound healing, colony formation, and cytotoxic effects of Quercetin-3-D-xyloside (reynoutrin), a quercetin derivative, in breast cancer cells Methods: In the present study, CRL-4010, MCF7 and MDA-MB-231 cells were used to evaluate the cytotoxic, antiproliferative and migration effects of reynoutrin on breast cancer. The IC50 concentration (400 mu g/ml) of reynoutrin, quercetin and cisplatin in the cells was determined. For cytotoxicity assessments, varying concentrations of quercetin, reynoutrin and cisplatin were applied and incubated 24h and 48h. In addition, to examine effects of reynoutrin on migration, cells were seeded in 6-well plates and incubated for 24 hours. For the colony formation assay cells were seeded to 12-well plates at a concentration of 1000 cells/well and incubated overnight. Results: These results indicated that reynoutrin markedly inhibit the cell viability in breast cancer. Conclusion: We have demonstrated for the first time with the present study that reynoutrin suppressed the progression of breast cancer cell proliferation induction and may provide a potential therapeutic target for breast cancer treatment. However, these results should be further confirmed by future more comprehensive studies.
Açıklama
Anahtar Kelimeler
Reynoutrin, Quercetin, Cytotoxicity, Breast Cancer, Migration, Cell-Cycle Arrest, Cisplatin Cytotoxicity, Antioxidant Activity, Flavonoids, Apoptosis, Statistics, Autophagy, Therapy
Kaynak
Journal of Basic and Clinical Health Sciences
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
6
Sayı
2
