Beneficial effects of resveratrol on scopolamine but not mecamylamine induced memory impairment in the passive avoidance and Morris water maze tests in rats

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dc.authorid0000-0001-7341-4907
dc.authorid0000-0003-0952-0742
dc.authorid0000-0003-0895-3490
dc.authorid0000-0001-5848-3680
dc.authorscopusid6603418006
dc.authorscopusid13405968200
dc.authorscopusid7003362092
dc.authorscopusid35331721100
dc.authorscopusid11440747800
dc.authorscopusid6603930475
dc.authorwosidUtkan, Tijen/G-2398-2018
dc.authorwosidulak, guner/F-5624-2018
dc.authorwosidMUTLU, OGUZ/F-5952-2018
dc.authorwosidgocmez, semil selcen/G-2401-2018
dc.authorwosidCelikyurt, Ipek Komsuoglu/F-7363-2018
dc.contributor.authorGacar, Nejat
dc.contributor.authorMutlu, Oğuz
dc.contributor.authorUtkan, Tijen
dc.contributor.authorÇelikyurt, İpek Komşuoğlu
dc.contributor.authorGöçmez, Semil Selcen
dc.contributor.authorUlak, Guner
dc.date.accessioned2022-05-11T14:41:08Z
dc.date.available2022-05-11T14:41:08Z
dc.date.issued2011
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.description.abstractResveratrol (3,5,4-trihydroxy-trans-stilbene), which is found in grapes and red wine has been shown to protect neuronal cells with its antioxidant activity, improve memory function in dementia and reverse acetylcholine esterase (AChE) activity. The aim of this study was to investigate the effect of resveratrol on emotional and spatial memory in naive rats, as well as on scopolamine- and mecamylamine-induced memory impairment in the passive avoidance and Morris water maze (MWM) tests. Resveratrol (12.5, 25 and 50 mg/kg), scopolamine (0.6 mg/kg) and mecamylamine (10 mg/kg) were administered to male Wistar rats. In the passive avoidance test, there was no significant difference in the first day latency between all groups, whereas scopolamine and mecamylamine significantly shortened the second day latency compared to the control group. Resveratrol reversed the effect of scopolamine at all doses used, but it had no effect on mecamylamine-induced memory impairment in the passive avoidance test. Both scopolamine and mecamylamine significantly decreased the time spent in the escape platform quadrant during the probe trial of the MWM test compared to the control group. Resveratrol reversed the effect of scopolamine at all doses, but did not change the effect of mecamylamine in the MWM test. There were no significant differences in the locomotor activities of any of the groups. In conclusion, we suggested that resveratrol had improving effects on learning and memory by acting on muscarinic cholinergic receptors and at least in part, may reverse AChE activity. (C) 2011 Elsevier Inc. All rights reserved.
dc.identifier.doi10.1016/j.pbb.2011.05.017
dc.identifier.endpage323
dc.identifier.issn0091-3057
dc.identifier.issue3en_US
dc.identifier.pmid21624386
dc.identifier.scopus2-s2.0-79959841848
dc.identifier.scopusqualityQ1
dc.identifier.startpage316
dc.identifier.urihttps://doi.org/10.1016/j.pbb.2011.05.017
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9078
dc.identifier.volume99
dc.identifier.wosWOS:000293371100005
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGöçmez, Semil Selcen
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofPharmacology Biochemistry and Behavior
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectResveratrol
dc.subjectCognition
dc.subjectMorris water maze
dc.subjectPassive avoidance
dc.subjectRat
dc.subjectLong-Term Potentiation
dc.subjectAspartate Receptor Antagonist
dc.subjectInduced Cognitive Impairment
dc.subjectTraumatic Brain-Injury
dc.subjectOxidative Stress
dc.subjectSelective Impairment
dc.subjectRecognition Memory
dc.subjectIn-Vivo
dc.subjectAcetylcholinesterase
dc.subjectWorking
dc.titleBeneficial effects of resveratrol on scopolamine but not mecamylamine induced memory impairment in the passive avoidance and Morris water maze tests in rats
dc.typeArticle

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