A Comparison of the Autologous Platelet-Rich Plasma Gel Fat Graft Myringoplasty and the Fat Graft Myringoplasty for the Closure of Different Sizes of Tympanic Membrane Perforations

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dc.authorscopusid55770607000
dc.authorscopusid26648338400
dc.contributor.authorErsözlü, Tolga
dc.contributor.authorGültekin, Erdoğan
dc.date.accessioned2022-05-11T14:36:05Z
dc.date.available2022-05-11T14:36:05Z
dc.date.issued2020
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kulak Burun ve Boğaz Hastalıkları Ana Bilim Dalı
dc.description.abstractObjective: We aimed to evaluate the effect of autologous platelet-rich plasma gel (PRPG) on fat graft myringoplasty (FGM) in tympanic membrane perforations caused by chronic otitis media. Methods: This retrospective study involved 63 patients who underwent operations between 2015 and 2018. Fat graft myringoplasty was performed with the transcanal approach with and without the use of PRPG in the surgical field. The patients were classified into 2 groups: group A, which included 32 patients who underwent FGM with the use of autologous PRPG, and group B, which included 31 patients who underwent FGM alone. Tympanic membrane perforations were divided into 2 groups: small perforations (1-2 mm) in a single quadrant and large perforations (2-4 mm) in at least 2 quadrants. Results: Both groups were statistically matched regarding age and sex. The mean postoperative follow-up was 11.6 and 12.1 months for groups A and B, respectively. Four months postoperatively, the success rate of the graft in group A (100%) was significantly higher than that in group B (83.8%; P = .03). The preoperative and postoperative median air-bone gaps of the groups were similar (P = .653 and P = .198, respectively). No worsening of the air-bone gap was noted postoperatively in either group. Conclusions: This study demonstrated that autologous PRPG application during FGM allows for a higher success rate than FGM alone. Furthermore, the use of PRPG with FGM for large perforations increases the success rate. Further studies are needed to investigate the PRPG healing effect on other tympanic membrane perforation closure techniques.
dc.identifier.doi10.1177/0145561319900388
dc.identifier.endpage336
dc.identifier.issn0145-5613
dc.identifier.issn1942-7522
dc.identifier.issue5en_US
dc.identifier.pmid31928083
dc.identifier.scopus2-s2.0-85078298849
dc.identifier.scopusqualityQ3
dc.identifier.startpage331
dc.identifier.urihttps://doi.org/10.1177/0145561319900388
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8365
dc.identifier.volume99
dc.identifier.wosWOS:000536211700021
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorErsözlü, Tolga
dc.institutionauthorGültekin, Erdoğan
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.ispartofEnt-Ear Nose & Throat Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectmyringoplasty
dc.subjectfat graft
dc.subjectplatelet-rich plasma gel
dc.subjecttympanic membrane
dc.subjectrepair
dc.subjectHyaluronic-Acid
dc.subjectFascia
dc.subjectRepair
dc.subjectPlug
dc.subjectTerm
dc.titleA Comparison of the Autologous Platelet-Rich Plasma Gel Fat Graft Myringoplasty and the Fat Graft Myringoplasty for the Closure of Different Sizes of Tympanic Membrane Perforations
dc.typeArticle

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