The impact of tomato fruits containing multi-walled carbon nanotube residues on human intestinal epithelial cell barrier function and intestinal microbiome composition

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dc.authorid0000-0002-7762-2006
dc.authorid0000-0002-9496-6636
dc.authorid0000-0002-6726-2502
dc.authorid0000-0003-0551-2606
dc.authorscopusid35253997800
dc.authorscopusid7101890733
dc.authorscopusid7102661232
dc.authorscopusid56218275200
dc.authorscopusid22734441900
dc.authorscopusid8643040800
dc.authorwosidBoy, Ramiz/J-9923-2017
dc.authorwosidKhare, SangeetA/Q-5470-2019
dc.authorwosidivanov, ilia/D-3402-2015
dc.contributor.authorLahiani, Mohamed H.
dc.contributor.authorKhare, Sangeeta
dc.contributor.authorCerniglia, Carl E.
dc.contributor.authorBoy, Ramiz
dc.contributor.authorIvanov, Ilia N.
dc.contributor.authorKhodakovskaya, Mariya
dc.date.accessioned2022-05-11T14:28:16Z
dc.date.available2022-05-11T14:28:16Z
dc.date.issued2019
dc.departmentFakülteler, Çorlu Mühendislik Fakültesi, Tekstil Mühendisliği Bölümü
dc.description.abstractCarbon nanomaterials (CNMs) can positively regulate seed germination and enhance plant growth. However, clarification of the impact of plant organs containing absorbed CNMs on animal and human health is a critical step of risk assessment for new nano-agro-technology. In this study, we have taken a comprehensive approach to studying the effect tomato fruits derived from plants exposed to multiwalled carbon nanotubes (CNTs) have on gastrointestinal epithelial barrier integrity and their impact on the human commensal intestinal microbiota using an in vitro cell culture and batch human fecal suspension models. The effects of CNTs on selected pure cultures of Salmonella enterica Typhimurium and Lactobacillus acidophilus were also evaluated. This study demonstrated that CNT-containing fruits or the corresponding residual level of pure CNTs (0.001 mu g ml(-1)) was not sufficient to initiate a significant change in transepithelial resistance and on gene expression of the model T-84 human intestinal epithelial cells. However, at 10 mu g ml(-1) concentration CNTs were able to penetrate the cell membrane and change the gene expression profile of exposed cells. Moreover, extracts from CNT-containing fruits had minimal to no effect on human intestinal microbiota as revealed by culture-based analysis and 16S rRNA sequencing.
dc.identifier.doi10.1039/c8nr08604d
dc.identifier.endpage3655
dc.identifier.issn2040-3364
dc.identifier.issn2040-3372
dc.identifier.issue8en_US
dc.identifier.pmid30741296
dc.identifier.scopus2-s2.0-85061993680
dc.identifier.scopusqualityQ1
dc.identifier.startpage3639
dc.identifier.urihttps://doi.org/10.1039/c8nr08604d
dc.identifier.urihttps://hdl.handle.net/20.500.11776/6743
dc.identifier.volume11
dc.identifier.wosWOS:000459504400020
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBoy, Ramiz
dc.language.isoen
dc.publisherRoyal Soc Chemistry
dc.relation.ispartofNanoscale
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChain Fatty-Acids
dc.subjectGut Microbiota
dc.subjectTight Junctions
dc.subjectToxicity
dc.subjectFood
dc.subjectNanoparticles
dc.subjectMicroflora
dc.subjectDiversity
dc.subjectBacteria
dc.subjectPlants
dc.titleThe impact of tomato fruits containing multi-walled carbon nanotube residues on human intestinal epithelial cell barrier function and intestinal microbiome composition
dc.typeArticle

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