Could the Systemic Inflammatory Response Index be a Marker for the Non-Dipper Pattern in Newly Diagnosed Hypertensive Patients?

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dc.authoridAydin, Cihan/0000-0002-1401-5727
dc.authoridCELIK, ENES/0000-0002-4540-7571
dc.contributor.authorKaplangoray, Mustafa
dc.contributor.authorToprak, Kenan
dc.contributor.authorCaglayan, Cuneyt
dc.contributor.authorDeveci, Edhem
dc.contributor.authorCelik, Enes
dc.contributor.authorUyan, Umut
dc.contributor.authorAydin, Cihan
dc.date.accessioned2025-04-06T12:23:54Z
dc.date.available2025-04-06T12:23:54Z
dc.date.issued2025
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractSystemic inflammatory response index (SIRI), is associated with prognosis in coronary artery disease (CAD), heart failure (HF), and acute myocardial infarction. This study investigated the relationship between SIRI and non-dipper hypertension. The study retrospectively included a total of 254 naive, newly diagnosed hypertensive individuals based on ambulatory blood pressure monitoring (ABPM), containing 166 dippers (DHT) and 88 non-dippers (NDHT). The SIRI value of all patients was calculated based on neutrophil, monocyte, and lymphocyte counts. The average age of study population was 50.7 +/- 9.4 years old, and the male ratio was 68.5%. Compared with DHT, patients in the NDHT group had higher SIRI, monocyte to HDL-C ratio (MHR), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), C-reactive protein (CRP), and neutrophil count, while high-density lipoprotein cholesterol (HDL-C) and lymphocyte count were lower (p < 0.05). The left ventricular mass index (LVMI) was higher in the NDHT group (p < 0.05). Multivariate logistic regression analysis showed that SIRI, LVMI, and HDL-C were independent predictor factors for NDHT. ROC curve analysis determined the optimal SIRI cut-off value for predicting NDHT diagnosis to be 2.41 (sensitivity 69.3%, specificity 64.5%, area under the receiver operating characteristic curve, 0.743; p < 0.001). The AUC values obtained for SIRI, MHR, NLR, PLR, HDL-C, and LVMI parameters in the ROC curve analysis were compared pairwise. The results demonstrated that SIRI's discriminative capacity in predicting NDHT was superior to all other indices. SIRI is an independent and significant predictor factor for NDHT and is superior in predicting NDHT diagnosis compared with HDL-C, MHR, LVMI, NLR, and PLR.
dc.description.sponsorshipScientific and Technological Research Council of Turkiye (TUBIdot;TAK)
dc.description.sponsorshipOpen access funding provided by the Scientific and Technological Research Council of Turkiye (TUB & Idot;TAK).
dc.identifier.doi10.1007/s12012-025-09977-3
dc.identifier.endpage569
dc.identifier.issn1530-7905
dc.identifier.issn1559-0259
dc.identifier.issue4
dc.identifier.pmid39992556
dc.identifier.scopus2-s2.0-85218692339
dc.identifier.scopusqualityQ1
dc.identifier.startpage559
dc.identifier.urihttps://doi.org/10.1007/s12012-025-09977-3
dc.identifier.urihttps://hdl.handle.net/20.500.11776/17251
dc.identifier.volume25
dc.identifier.wosWOS:001432442500001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherHumana Press Inc
dc.relation.ispartofCardiovascular Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250406
dc.subjectSystemic inflammatory response index
dc.subjectHypertension
dc.subjectInflammatory
dc.subjectNon-dipper
dc.titleCould the Systemic Inflammatory Response Index be a Marker for the Non-Dipper Pattern in Newly Diagnosed Hypertensive Patients?
dc.typeArticle

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