Are fungi and EBV effective in cholesteatoma etiology?

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dc.contributor.authorKarabağ, Sevil
dc.contributor.authorErsözlü, Tolga
dc.contributor.authorİsal Arslan, Ayşegül
dc.date.accessioned2023-05-06T17:19:33Z
dc.date.available2023-05-06T17:19:33Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kulak Burun ve Boğaz Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kulak Burun ve Boğaz Hastalıkları Ana Bilim Dalı
dc.description.abstractAim: Cholesteatoma is a commonly seen disease whose pathogenesis remains unknown. Although not a neoplastic process, it may progress to a fatal condition with local bone destruction. In this study, we aimed to present new insights concerning the etiology of cholesteatoma triggered by an inflammatory process.Materials and Methods: The study included 34 patients diagnosed with cholesteatoma upon mastoidectomy performed between 2011-2019. Due to a provisional diagnosis of cholesteatoma. The cases were investigated for the latent membrane protein (LMP-1) encoded by the Epstein-Barr Virus (EBV) using the immunohistochemical method and for the presence of fungi using Grocott’s methenamine silver (GMSII) stain.Results: No fungi was detected in any of the 34 patients by GMSII staining. Thirty-two of the 34 patients were negative with but a suspicious result was seen in 2 patients with the immunohistochemical EBV antibody. EBV-encoded RNA (EBER) analysis was applied to these 2 cases with the silver in situ hybridization method and no reaction was observed.Conclusion: In our study, we investigated the presence of fungi and EBV, which can trigger the inflammatory process. However, no EBV or fungi was detected in the tissues. Our study is the first to investigate the presence of EBV and fungi in formalin-fixed tissue in cases of aggressive cholesteatoma.
dc.identifier.doi10.30569/adiyamansaglik.1034935
dc.identifier.endpage128
dc.identifier.issn2458-9179
dc.identifier.issue2en_US
dc.identifier.startpage123
dc.identifier.trdizinid1131445
dc.identifier.urihttps://doi.org/10.30569/adiyamansaglik.1034935
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1131445
dc.identifier.urihttps://hdl.handle.net/20.500.11776/11847
dc.identifier.volume8
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorKarabağ, Sevil
dc.institutionauthorErsözlü, Tolga
dc.institutionauthorİsal Arslan, Ayşegül
dc.language.isoen
dc.relation.ispartofAdıyaman Üniversitesi Sağlık Bilimleri Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCholesteatoma
dc.subjectEtiology
dc.subjectFungi
dc.subjectEBV Kolesteatom
dc.subjectEtyoloji
dc.subjectMantar
dc.subjectEBV
dc.titleAre fungi and EBV effective in cholesteatoma etiology?
dc.typeArticle

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