Interaction of Metabolic Syndrome with Asthma in Postmenopausal Women: Role of Adipokines

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dc.authorscopusid7102765266
dc.authorscopusid15020620800
dc.authorscopusid12783287500
dc.authorscopusid36437824000
dc.authorscopusid7003361285
dc.authorscopusid36617408300
dc.authorscopusid6701593878
dc.contributor.authorAydın, Murat
dc.contributor.authorKoca, Cemile
dc.contributor.authorÖzol, Duygu
dc.contributor.authorUysal, Sema
dc.contributor.authorYıldırım, Zeki
dc.contributor.authorKavaklı, Havva Sahin
dc.contributor.authorYigitoglu, M. Ramazan
dc.date.accessioned2022-05-11T14:42:05Z
dc.date.available2022-05-11T14:42:05Z
dc.date.issued2013
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractThe increasing prevalence of both asthma and obesity are major health problems. Recent studies established a possible link between obesity and asthma; however, the underlying mechanism is not clear. The aim of the study was to analyze the prevalence of metabolic syndrome in postmenopausal subjects with asthma and search the interactions between adipokines, metabolic syndrome, and asthma. A total of 45 female patients (57.5 +/- 13.9 years) with asthma and 30 healthy subjects (59.6 +/- 12.8 years) in postmenopausal status were enrolled in this study. For the diagnosis of metabolic syndrome, modified World Health Organization diagnostic criteria were used. Blood levels of glucose, lipid profile, HbA1c, insulin, CRP, leptin, adiponectin, tumor necrosis factor-alpha, interleukin (IL)-6, IL-8 and plasminogen activator inhibitor-1 (PAI-1) were measured. The mean body mass index was 29.6 +/- 5.4 for asthma patients and 28.2 +/- 5.3 for the control group. The incidence of metabolic syndrome was found as 26 % for both groups. Insulin resistance as calculated by homeostasis model assessment (HOMA-IR) and fasting insulin levels were significantly higher in asthma patients (p < 0.001 for both parameters). Leptin levels were significantly higher (p = 0.001) and adiponectin levels were lower (p = 0.029) in asthma patients compared to controls. We concluded that although incidence of obesity and metabolic syndrome was not higher in postmenopausal asthma patients than controls, there was an impairment of glucose metabolism and altered adipokine levels in asthma patients.
dc.description.sponsorshipScientific Research Fund of Fatih UniversityFatih University [P53010703]
dc.description.sponsorshipThe authors wish to express their sincere appreciation to the study participants and to Fatih University. This work was financially supported by the Scientific Research Fund of Fatih University under the project number P53010703.
dc.identifier.doi10.1007/s10753-013-9660-9
dc.identifier.endpage1238
dc.identifier.issn0360-3997
dc.identifier.issn1573-2576
dc.identifier.issue6en_US
dc.identifier.pmid23729278
dc.identifier.scopus2-s2.0-84888197888
dc.identifier.scopusqualityQ2
dc.identifier.startpage1232
dc.identifier.urihttps://doi.org/10.1007/s10753-013-9660-9
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9209
dc.identifier.volume36
dc.identifier.wosWOS:000326692200006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAydın, Murat
dc.language.isoen
dc.publisherSpringer/Plenum Publishers
dc.relation.ispartofInflammation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectadiponectin
dc.subjectadipose tissue
dc.subjectinsulin resistance
dc.subjectinflammation
dc.subjectleptin
dc.subjectasthma
dc.subjectBody-Mass Index
dc.subjectInsulin-Resistance
dc.subjectIncident Asthma
dc.subjectRisk-Factor
dc.subjectObesity
dc.subjectAssociation
dc.subjectLeptin
dc.subjectInflammation
dc.subjectAdults
dc.titleInteraction of Metabolic Syndrome with Asthma in Postmenopausal Women: Role of Adipokines
dc.typeArticle

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