Granulocyte colony-stimulating factor has a sex-dependent positive effect in the maternal immune activation-induced autism model

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dc.authoridErdogan, Mumin/0000-0003-0048-444X
dc.authorscopusid55315126400
dc.authorscopusid29067508300
dc.authorscopusid45661021700
dc.authorscopusid55892061800
dc.authorscopusid57189713929
dc.authorscopusid55469991100
dc.contributor.authorDurankuş, Ferit
dc.contributor.authorAlbayrak, Yakup
dc.contributor.authorErdoğan, Fırat
dc.contributor.authorAlbayrak, Neslihan
dc.contributor.authorErdoğan, Mumin Alper
dc.contributor.authorErbaş, Oytun
dc.date.accessioned2023-04-20T08:01:14Z
dc.date.available2023-04-20T08:01:14Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Ruh Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractObjective The medical intervention for autism spectrum disorder (ASD) is restricted to ameliorating comorbid situations. Granulocyte colony-stimulating factor (G-CSF) is a growth factor that enhances the proliferation, differentiation, and survival of hematopoietic progenitor cells. In the present study, we aimed to investigate the effects of G-CSF in a maternal immune activation-induced autism model. Methods Sixteen female and six male Wistar adult rats were included in the study. After 21 days, 48 littermates (eight male controls, eight female controls, 16 male lipopolysaccharide [LPS]-exposed rats, and 16 female LPS-exposed rats) were divided into groups. Sixteen male LPS-exposed and 16 female LPS-exposed rats were divided into saline and G-CSF treatment groups. Results In male rats, the LPS-exposed group was found to have significantly higher levels of TNF-alpha, IL-2, and IL-17 than the LPS-exposed G-CSF group. Levels of nerve growth factor, brain PSD-95, and brain GAD67 were higher in the LPS-exposed G-CSF group than in the LPS-exposed group in male rats. In female rats, brain NGF levels were similar between groups. There was no difference between groups in terms of brain GAD 67 levels. Brain PSD-95 levels were higher in the control group than in both the LPS-exposed and LPS-exposed G-CSF groups in female rats. Both neuronal CA1 and neuronal CA2 levels were lower, and the GFAP immunostaining index (CA1) and GFAP immunostaining index (CA3) were higher in the LPS-exposed group than in the LPS-exposed G-CSF group in male rats. However, neuronal count CA1 and neuronal count CA3 values were found to be similar between groups in female rats. Conclusions The present research is the first to demonstrate the beneficial effects of G-CSF on core symptoms of ASD experimentally depending on male sex. G-CSF can be a good candidate for ameliorating the core symptoms of ASD without serious side effects in males.
dc.identifier.doi10.1002/jdn.10221
dc.identifier.issn0736-5748
dc.identifier.issn1873-474X
dc.identifier.pmid35904498
dc.identifier.scopus2-s2.0-85135862550
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1002/jdn.10221
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10813
dc.identifier.wosWOS:000839979400001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAlbayrak, Yakup
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofInternational Journal of Developmental Neuroscience
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAutism
dc.subjectExperimental
dc.subjectGranulocyte Colony-Stimulating Factor
dc.subjectTreatment
dc.subjectAmyotrophic-Lateral-Sclerosis
dc.subjectNerve Growth-Factor
dc.subjectPrenatal Infection
dc.subjectMouse Model
dc.subjectExpression
dc.subjectBehavior
dc.subjectBrain
dc.subjectMice
dc.subjectAssociation
dc.subjectPhenotypes
dc.titleGranulocyte colony-stimulating factor has a sex-dependent positive effect in the maternal immune activation-induced autism model
dc.typeArticle

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