Efficacy of ultrasound-guided Transversus Abdominis Plane (TAP) block in inguinal hernia surgery and the immunomodulatory effects of proinflammatory cytokines: prospective, randomized, placebo-controlled study

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dc.authorid0000-0001-6611-7226
dc.authorid0000-0003-2093-9229
dc.authorscopusid6507396652
dc.authorscopusid16400777600
dc.authorscopusid57204251880
dc.authorscopusid46061791900
dc.authorscopusid56410672800
dc.authorscopusid25936860600
dc.authorwosidCihan, Murat/ABG-8303-2021
dc.authorwosidCanakci, Ebru/AAO-6761-2020
dc.authorwosidCanakci, Ebru/A-4429-2018
dc.contributor.authorÇanakçı, Ebru
dc.contributor.authorCihan, Murat
dc.contributor.authorAltinbas, Ali
dc.contributor.authorCebeci, Zübeyir
dc.contributor.authorGültekin, Ahmet
dc.contributor.authorTaş, Nilay
dc.date.accessioned2022-05-11T14:34:44Z
dc.date.available2022-05-11T14:34:44Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Anesteziyoloji ve Reanimasyon Ana Bilim Dalı
dc.description.abstractBackground: Tumor Necrosis Factor -a (TNF-a) and Interleukin-113 (IL-113) are among the cytokines released secondary to the surgical stress response. The objective of this study was to investigate the effect of a Transversus Abdominis Plane (TAP) block on postoperative pain and its immunomodulatory activity through proinflammatory cytokines. Methods: TAP (study group; n = 40) or p-TAP (placebo group; n = 40). Patients in the TAP group underwent an Ultrasound (US) guided unilateral TAP block using 20-cc 0.5% bupivacaine solution. Patients in the p-TAP group underwent a sham block using 20-cc isotonic solution. The TNF-a and IL-113 levels were measured three times at preoperative hour-0 and postoperative hours 4 and 24. Visual Analog Scale (VAS) scores were recorded at 0-hours, 30-minutes, 4-hours, and 24-hours. Analgesic use within the first 24-hours following surgery was monitored. Results: The postoperative VAS score was decreased in the TAP group at all time points (0, 4, and 24 hours), and the differences between groups were statistically significant (p < 0.001 for all comparisons). In the TAP group, the TNF-a and IL-113 levels at 4 and 24 hours post operation were significantly lower than the preoperative levels (p < 0.001 for all comparisons). Conclusion: The TAP block for pre-emptive analgesia enabled effective hemodynamic control during the intraoperative period, provided effective pain control in the postoperative period, and decreased inflammation and surgical stress due to the decreased levels of the proinflamma-tory cytokines TNF-ec and IL-1 beta in the first postoperative 24 hours, indicating immunomodulatory effect. (c) 2021 Published by Elsevier Editora Ltda. on behalf of Sociedade Brasileira de Anestesiologia. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/).
dc.identifier.doi10.1016/j.bjane.2021.02.005
dc.identifier.endpage544
dc.identifier.issn0104-0014
dc.identifier.issn2352-2291
dc.identifier.issue5en_US
dc.identifier.pmid34537124
dc.identifier.scopus2-s2.0-85120360683
dc.identifier.scopusqualityQ3
dc.identifier.startpage538
dc.identifier.urihttps://doi.org/10.1016/j.bjane.2021.02.005
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8071
dc.identifier.volume71
dc.identifier.wosWOS:000739668300012
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGültekin, Ahmet
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofBrazilian Journal of Anesthesiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectImmunomodulation
dc.subjectPain control
dc.subjectProinflammatory cytokines
dc.subjectTransversus abdominis plane block
dc.subjectNeuroendocrine Stress-Response
dc.subjectAnalgesic Efficacy
dc.subjectRepair
dc.titleEfficacy of ultrasound-guided Transversus Abdominis Plane (TAP) block in inguinal hernia surgery and the immunomodulatory effects of proinflammatory cytokines: prospective, randomized, placebo-controlled study
dc.typeArticle

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