Different disease subtypes with distinct clinical expression in familial Mediterranean fever: results of a cluster analysis

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dc.authorid0000-0001-7737-4180
dc.authorid0000-0002-0783-1072
dc.authorscopusid7004438602
dc.authorscopusid57208486786
dc.authorscopusid8392501600
dc.authorscopusid55924558000
dc.authorscopusid56985556700
dc.authorscopusid56411884200
dc.authorscopusid6701365996
dc.authorwosidSARI, Ismail/E-1778-2011
dc.authorwosidTunca, Mehmet/R-8574-2019
dc.authorwosidBilge, Nazife Sule Yasar/AAD-1796-2021
dc.contributor.authorAkar, Servet
dc.contributor.authorSolmaz, Dilek
dc.contributor.authorKaşifoğlu, Timuçin
dc.contributor.authorYaşar Bilge, Şule
dc.contributor.authorSarı, İsmail
dc.contributor.authorGümüş, Zeynep Zehra
dc.contributor.authorTunca, Mehmet
dc.date.accessioned2022-05-11T14:39:54Z
dc.date.available2022-05-11T14:39:54Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractObjective. The aim of this study was to evaluate whether there are clinical subgroups that may have different prognoses among FMF patients. Methods. The cumulative clinical features of a large group of FMF patients [1168 patients, 593 (50.8%) male, mean age 35.3 years (S.D. 12.4)] were studied. To analyse our data and identify groups of FMF patients with similar clinical characteristics, a two-step cluster analysis using log-likelihood distance measures was performed. For clustering the FMF patients, we evaluated the following variables: gender, current age, age at symptom onset, age at diagnosis, presence of major clinical features, variables related with therapy and family history for FMF, renal failure and carriage of M694V. Results. Three distinct groups of FMF patients were identified. Cluster 1 was characterized by a high prevalence of arthritis, pleuritis, erysipelas-like erythema (ELE) and febrile myalgia. The dosage of colchicine and the frequency of amyloidosis were lower in cluster 1. Patients in cluster 2 had an earlier age of disease onset and diagnosis. M694V carriage and amyloidosis prevalence were the highest in cluster 2. This group of patients was using the highest dose of colchicine. Patients in cluster 3 had the lowest prevalence of arthritis, ELE and febrile myalgia. The frequencies of M694V carriage and amyloidosis were lower in cluster 3 than the overall FMF patients. Non-response to colchicine was also slightly lower in cluster 3. Conclusion. Patients with FMF can be clustered into distinct patterns of clinical and genetic manifestations and these patterns may have different prognostic significance.
dc.identifier.doi10.1093/rheumatology/kev315
dc.identifier.endpage346
dc.identifier.issn1462-0324
dc.identifier.issn1462-0332
dc.identifier.issue2en_US
dc.identifier.pmid26370398
dc.identifier.scopus2-s2.0-84961950223
dc.identifier.scopusqualityQ1
dc.identifier.startpage343
dc.identifier.urihttps://doi.org/10.1093/rheumatology/kev315
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8787
dc.identifier.volume55
dc.identifier.wosWOS:000370205200022
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSolmaz, Dilek
dc.language.isoen
dc.publisherOxford Univ Press
dc.relation.ispartofRheumatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectfamilial Mediterranean fever
dc.subjectcluster analysis
dc.subjectmarenostrin
dc.subjectphenotype
dc.subjectMulticenter
dc.subjectAmyloidosis
dc.titleDifferent disease subtypes with distinct clinical expression in familial Mediterranean fever: results of a cluster analysis
dc.typeArticle

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