Salvage Treatment Experience in Advanced Synovial Sarcoma: a Multicenter Retrospective Analysis of the Anatolian Society of Medical Oncology

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dc.authorid0000-0001-9081-2405
dc.authorid0000-0002-4833-6721
dc.authorscopusid8666331800
dc.authorscopusid36112602800
dc.authorscopusid6701472672
dc.authorscopusid24504259900
dc.authorscopusid35746413400
dc.authorscopusid55550154500
dc.authorscopusid6701753460
dc.authorwosidKucukoner, Mehmet/E-1162-2013
dc.authorwosidGumus, Mahmut/C-7135-2008
dc.authorwosidseber, selcuk/T-9539-2019
dc.authorwosidKos, Tugba/D-8952-2016
dc.contributor.authorYetişyiğit, Tarkan
dc.contributor.authorArpacı, Erkan
dc.contributor.authorŞeber, Erdoğan Selçuk
dc.contributor.authorKüçüköner, Mehmet
dc.contributor.authorKöş, Fatma Tuğba
dc.contributor.authorUysal Sönmez, Özlem
dc.contributor.authorGümüş, Mahmut
dc.date.accessioned2022-05-11T14:40:55Z
dc.date.available2022-05-11T14:40:55Z
dc.date.issued2013
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyasyon Onkolojisi Ana Bilim Dalı
dc.description.abstractBackground: We aimed to evaluate prognostic factors and response rates to various treatment approaches to patients with synovial sarcoma in an advanced setting. Materials and Methods: We retrospectively reviewed the medical records of 55 patients (18 pts; 32.7% women) diagnosed with synovial sarcomas. Twenty had metastatic disease at the time of diagnosis while the remainder of the study group consisted of patients who developed metastatic or inoperable locally advanced disease during follow up. Results: The median follow up time was 15 months (range: 1-53). Regarding outcomes for the 55 patients, 3 and 5 year overall survival rates were 26% and 14%, respectively. In univariate analyses among demographic factors female gender was associated with a better outcome (p=0.030). Patients with early progressing disease (<2 years) had a worse prognosis when compared to patient group with late relapse, but this difference did not reach statistical significance (p=0.056). According to multivariate Cox regression analysis patients who had undergone metastasectomy had a significant survival advantage (p=0.044). The overall response rate to different salvage chemotherapy regimens given as second line treatment was around 42.9-53.9% for all regimes. There were no statistically significant differences between chemotherapy regimens given in either second or third line settings in terms of overall survival. Conclusions: We observed no major differences in terms of response rate and survival between different salvage chemotherapy regimens. Although metastatic disease still carries a poor prognosis, metastasectomy was found to be associated with improved survival
dc.identifier.doi10.7314/APJCP.2013.14.9.5185
dc.identifier.endpage5188
dc.identifier.issn1513-7368
dc.identifier.issue9en_US
dc.identifier.pmid24175798
dc.identifier.scopus2-s2.0-84887582433
dc.identifier.scopusqualityQ3
dc.identifier.startpage5185
dc.identifier.urihttps://doi.org/10.7314/APJCP.2013.14.9.5185
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8970
dc.identifier.volume14
dc.identifier.wosWOS:000328273000042
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYetişyiğit, Tarkan
dc.language.isoen
dc.publisherAsian Pacific Organization Cancer Prevention
dc.relation.ispartofAsian Pacific Journal of Cancer Prevention
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSynovial sarcoma
dc.subjectadvanced disease
dc.subjectsalvage chemotherapy
dc.subjectprognostic factors
dc.subjectmetastasectomy
dc.subjectAdvanced Soft-Tissue
dc.subjectPrognostic-Factors
dc.subjectBone Sarcoma
dc.subjectEuropean Organization
dc.subjectPhase-Ii
dc.subjectChemotherapy
dc.subjectGemcitabine
dc.subjectDocetaxel
dc.subjectBenefit
dc.titleSalvage Treatment Experience in Advanced Synovial Sarcoma: a Multicenter Retrospective Analysis of the Anatolian Society of Medical Oncology
dc.typeArticle

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