Protective Effects of Onion Extract on Cadmium-Induced Oxidative Stress, Histological Damage, and Apoptosis in Rat Heart

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dc.authorscopusid6505680586
dc.authorscopusid7006356462
dc.authorscopusid24436194200
dc.authorscopusid36023238400
dc.authorscopusid16315021800
dc.authorscopusid26532378600
dc.authorscopusid55881189500
dc.authorwosidAlpsoy, Seref/Z-1808-2018
dc.authorwosidAktas, Cevat/D-8468-2011
dc.contributor.authorAlpsoy, Şeref
dc.contributor.authorKanter, Mehmet
dc.contributor.authorAktaş, Cevat
dc.contributor.authorErboğa, Mustafa
dc.contributor.authorAkyüz, Aydın
dc.contributor.authorAkkoyun, Dursun Çayan
dc.contributor.authorOran, Mustafa
dc.date.accessioned2022-05-11T14:10:05Z
dc.date.available2022-05-11T14:10:05Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractTo date, there is no available information on the protective effect of onion (Allium cepa) extract (AcE) on cadmium (Cd)-induced cardiotoxicity. The present study was performed to assess the possible antioxidant and anti-apoptotic roles of AcE in Cd-induced cardiotoxicity in rats. A Cd group was injected subcutaneously with CdCl2 dissolved in saline at a dose of 2 ml/kg/day for 30 days, resulting in a dosage of 1 mg/kg Cd. The rats in the AcE-treated group were given 1 ml of AcE via intragastric intubation for 30 days. The rats intoxicated with Cd for 30 days showed increased tissue malondialdehyde (MDA) levels and decreased levels of the enzymatic antioxidants superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) in cardiac tissue. AcE attenuated these adverse effects of Cd. After Cd exposure, histological abnormalities were observed, including myofibrillar loss, vacuolization of cytoplasm and irregularity of myofibrils. These histological alterations were effectively attenuated by the treatment with AcE. Furthermore, our data indicate a significant reduction of apoptosis in the cardiomyocytes of the Cd group treated with AcE therapy. Animal studies show antioxidant effects of AcE. But to date, no study reported the effect of AcE on biochemical and histopathological changes due to Cd induced on rat heart. Our study showed that AcE therapy reduced Cd-induced oxidative stress and apoptosis, possibly through its antioxidant and anti-apoptotic activity.
dc.identifier.doi10.1007/s12011-014-9968-9
dc.identifier.endpage303
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue45352en_US
dc.identifier.pmid24736979
dc.identifier.scopus2-s2.0-84902536764
dc.identifier.scopusqualityQ1
dc.identifier.startpage297
dc.identifier.urihttps://doi.org/10.1007/s12011-014-9968-9
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5278
dc.identifier.volume159
dc.identifier.wosWOS:000337284300037
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAlpsoy, Şeref
dc.institutionauthorAktaş, Cevat
dc.institutionauthorErboğa, Mustafa
dc.institutionauthorAkyüz, Aydın
dc.institutionauthorAkkoyun, Dursun Çayan
dc.institutionauthorOran, Mustafa
dc.language.isoen
dc.publisherHumana Press Inc
dc.relation.ispartofBiological Trace Element Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCadmium
dc.subjectCardiotoxicity
dc.subjectAllium cepa
dc.subjectTUNEL
dc.subjectOxidative stress
dc.subjectInduced Cardiac Impairment
dc.subjectGarlic Extracts
dc.subjectAntioxidant
dc.subjectInvolvement
dc.subjectExposure
dc.subjectDisease
dc.subjectRisk
dc.titleProtective Effects of Onion Extract on Cadmium-Induced Oxidative Stress, Histological Damage, and Apoptosis in Rat Heart
dc.typeArticle

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