Asymmetric response properties of rapidly adapting mechanoreceptive fibers in the rat glabrous skin

Basit Öğe Kaydı
dc.authorid0000-0003-4119-617X
dc.authorid0000-0002-7757-5764
dc.authorscopusid55597343100
dc.authorscopusid6603560243
dc.authorwosidDEVECIOGLU, ISMAIL/H-4523-2018
dc.contributor.authorDevecioğlu, İsmail
dc.contributor.authorGüçlü, Burak
dc.date.accessioned2022-05-11T14:16:00Z
dc.date.available2022-05-11T14:16:00Z
dc.date.issued2013
dc.departmentFakülteler, Çorlu Mühendislik Fakültesi, Biyomedikal Mühendisliği Bölümü
dc.description.abstractPrevious histological and neurophysiological studies have shown that the innervation density of rapidly adapting (RA) mechanoreceptive fibers increases towards the fingertip. Since the psychophysical detection threshold depends on the contribution of several RA fibers, a high innervation density would imply lower thresholds. However, our previous human study showed that psychophysical detection thresholds for the Non-Pacinian I channel mediated by RA fibers do not improve towards the fingertip. By recording single-unit spike activity from rat RA fibers, here we tested the hypothesis that the responsiveness of RA fibers is asymmetric in the proximo-distal axis which may counterbalance the effects of innervation density. RA fibers (n = 32) innervating the digital glabrous skin of rat hind paw were stimulated with 40-Hz sinusoidal mechanical bursts at five different stimulus locations relative to the receptive field (RF) center (two distal, one RF center, two proximal). Different contactor sizes (area: 0.39, 1.63, 2.96 mm(2)) were used. Rate-intensity functions were constructed based on average firing rates, and the absolute spike threshold and the entrainment threshold were obtained for each RA fiber. Thresholds for proximal stimulus locations were found to be significantly higher than those for distal stimulus locations, which suggests that the mechanical stimulus is transmitted better towards the proximal direction. The effect of contactor size was not significant. Mechanical impedance of the rat digital glabrous skin was further measured and a lumped-parameter model was proposed to interpret the relationship between the asymmetric response properties of RA fibers and the mechanical properties of the skin.
dc.description.sponsorshipBogazici University BAPBogazici University [10XP1]; Ministry of Development DPTTurkiye Cumhuriyeti Kalkinma Bakanligi [09K120520]
dc.description.sponsorshipWe would like to thank Lorraine Pawson and Adam Pack from Syracuse University for helpful discussions. This study was supported by Bogazici University BAP no. 10XP1 and Ministry of Development DPT project no. 09K120520 to Burak Guclu.
dc.identifier.doi10.3109/08990220.2012.732128
dc.identifier.endpage29
dc.identifier.issn0899-0220
dc.identifier.issue1en_US
dc.identifier.pmid23176144
dc.identifier.scopus2-s2.0-84873888852
dc.identifier.scopusqualityN/A
dc.identifier.startpage16
dc.identifier.urihttps://doi.org/10.3109/08990220.2012.732128
dc.identifier.urihttps://hdl.handle.net/20.500.11776/6147
dc.identifier.volume30
dc.identifier.wosWOS:000314778400002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDevecioğlu, İsmail
dc.language.isoen
dc.publisherInforma Healthcare
dc.relation.ispartofSomatosensory and Motor Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSomatosensation
dc.subjecttactile fiber
dc.subjectrate-intensity function
dc.subjectvibrotactile stimulus
dc.subjectlumped-parameter model
dc.subjectrat
dc.subjectReceptive-Field Characteristics
dc.subjectHuman Hand
dc.subjectPopulation Responses
dc.subjectTactile Sensibility
dc.subjectSensory Receptors
dc.subjectAfferent Units
dc.subjectHuman Capacity
dc.subjectProbe Array
dc.subjectMonkey Hand
dc.subjectStimulus
dc.titleAsymmetric response properties of rapidly adapting mechanoreceptive fibers in the rat glabrous skin
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
6147.pdf
Boyut:
866.97 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Çorlu Mühendislik Fakültesi Koleksiyonu