Chemical Profile, Antiproliferative and Antioxidant Activities of Genista januensis subsp. lydia (Boiss.) Kit Tan & Ziel (Fabaceae)

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dc.contributor.authorArgon, Merve
dc.contributor.authorSabudak, Temine
dc.contributor.authorYildirim, Buse Nur
dc.contributor.authorBatar, Bahadir
dc.contributor.authorOrak, Hakime Hulya
dc.contributor.authorYabas, Mehmet
dc.contributor.authorBostanci, Ayten
dc.date.accessioned2025-04-06T12:23:42Z
dc.date.available2025-04-06T12:23:42Z
dc.date.issued2025
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractThe aim of this study was to investigate the anticancer and antioxidant activities of Genista januensis subsp. lydia (Fabaceae) extracts and to isolate the phytochemical compounds responsible for these activities. The G. januensis plant was extracted by maceration with solvents of increasing polarity. The total phenolic/flavonoid content, antioxidant activities and anticancer activity were investigated by performing cytotoxicity, apoptosis and cell cycle analyses in crude extracts. We found that the EtOAc extract had the highest antioxidant and anticancer activities and this extract was selected for isolation studies. All purified flavonoid compounds from the EtOAc extract were elucidated using 1D and 2D NMR and mass spectroscopic methods and compared with the literature. A new biflavonoid 4 was isolated together with three known isoflavonoids (genistein (1), genistin (2) and 4'-hydroxyisoflavone (3)) from Genista januensis subsp. lydia (Fabaceae). MTT analysis of compounds 2, 3, and 4 was used to evaluate the anticancer activity. Compound 4 was invesigated for its antioxidant activities. These findings suggest that G. januensis subsp. lydia represents new potential natural sources of effective antiproliferative and antioxidant agents.
dc.description.sponsorshipScientific Research Projects Coordination Unit of Tekirdag Namik Kemal University [NKUBAP.01.OENAP.21.318]; Council of Higher Education (YOK) [100/2000]
dc.description.sponsorshipDeclaration of Competing Interest The authors declare that they have no competing in-terests.This study was funded by the Scientific Research Projects Coordination Unit of Tekirdag Namik Kemal University. Project number: NKUBAP.01.OENAP.21.318.Buse Nur Y & imath;ld & imath;r & imath;m is also grateful for the PhD Scholarship Programme of the Council of Higher Education (YOK, 100/2000) , Turkiye.
dc.identifier.doi10.17344/acsi.2024.8957
dc.identifier.endpage62
dc.identifier.issn1318-0207
dc.identifier.issn1580-3155
dc.identifier.issue1
dc.identifier.pmid40109057
dc.identifier.scopus2-s2.0-105001026895
dc.identifier.scopusqualityQ3
dc.identifier.startpage52
dc.identifier.urihttps://doi.org/10.17344/acsi.2024.8957
dc.identifier.urihttps://hdl.handle.net/20.500.11776/17148
dc.identifier.volume72
dc.identifier.wosWOS:001451117400006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSlovensko Kemijsko Drustvo
dc.relation.ispartofActa Chimica Slovenica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250406
dc.subjectGenista januensis subsp. lydia
dc.subjectbiflavonoid
dc.subjectantiproliferative effect
dc.subjectisoflavonoids
dc.subjectantioxidant activity
dc.titleChemical Profile, Antiproliferative and Antioxidant Activities of Genista januensis subsp. lydia (Boiss.) Kit Tan & Ziel (Fabaceae)
dc.typeArticle

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