Comparison of Before and After Varicocelectomy Levels of Trace Elements, Nitric Oxide, Asymmetric Dimethylarginine and Malondialdehyde in the Seminal Plasma and Peripheral and Spermatic Veins

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dc.authorid0000-0001-6140-5181
dc.authorscopusid6508166517
dc.authorscopusid8713588200
dc.authorscopusid23968920100
dc.authorscopusid8416588900
dc.authorscopusid6508253764
dc.authorscopusid35264829200
dc.authorscopusid56406174400
dc.authorwosidMalkoc, Ercan/AAJ-3012-2020
dc.authorwosidYazici, Cenk Murat/AAA-4330-2020
dc.contributor.authorKızıler, Ali Rıza
dc.contributor.authorAydemir, Birsen
dc.contributor.authorGüzel, Savaş
dc.contributor.authorYaman, Ali
dc.contributor.authorGulyasar, Tevfik
dc.contributor.authorMalkoc, Ercan
dc.contributor.authorAcar, Ayşe
dc.contributor.authorYazıcı, Cenk Murat
dc.date.accessioned2022-05-11T14:12:32Z
dc.date.available2022-05-11T14:12:32Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.description.abstractIncreased oxidative damage has been suggested to play an important role in the spermatogenesis and sperm function changes in patients with varicocele. However, changes in levels of nitric oxide (NO), asymmetric dimethylarginine (ADMA), malondialdehyde (MDA), iron (Fe), zinc (Zn) and copper (Cu) in blood and seminal plasma, and semen quality, are unknown. The aim of this study was to investigate the NO, ADMA, Fe, Cu, Zn and MDA levels from seminal plasma and peripheral and spermatic vein blood samples of patients with varicocele before and after varicocelectomy. In this before and after comparative study, 29 consecutive patients attending a training hospital in Tekirdag, Turkey, were recruited. MDA and NO levels were determined by spectrophotometric methods. The levels of ADMA were determined by enzyme-linked immunosorbent assay method. Trace element level was determined by atomic absorption spectrophotometric method. The levels of MDA in the seminal plasma and peripheral and spermatic vein samples were observed to decrease significantly in the comparison of before and after phases of the study group (p= 0.022, p= 0.001 and p= 0.034, respectively). Also, the levels of NO in the seminal plasma and spermatic vein samples decreased significantly in the comparison of before and after phases of the study group (p= 0.025 and p= 0.001, respectively), while the levels of ADMA in seminal plasma and spermatic vein samples increased significantly in the comparison of before and after phases of the study group (p= 0.003 and p= 0.001, respectively). There were no significant differences in the levels of trace elements and sperm count (p> 0.05). Oxidative stress is significantly higher in the spermatic vein and seminal plasma samples of patients with varicocele before varicocelectomy. In conclusion, these events may be evaluated accordingly for the potentially beneficial treatment methods.
dc.description.sponsorshipNamik Kemal UniversityNamik Kemal University [NKUBAP.00.20.AR.12.06]
dc.description.sponsorshipThis study was supported by The Research Fund of Namik Kemal University (Project Number NKUBAP.00.20.AR.12.06). This study was also presented in the Annual Meeting of the German Biophysical Society (DGfB) that took place on 14-17 September 2014 in the University of Lubeck, Germany.
dc.identifier.doi10.1007/s12011-015-0303-x
dc.identifier.endpage178
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue2en_US
dc.identifier.pmid25787826
dc.identifier.scopus2-s2.0-84941181074
dc.identifier.scopusqualityQ1
dc.identifier.startpage172
dc.identifier.urihttps://doi.org/10.1007/s12011-015-0303-x
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5592
dc.identifier.volume167
dc.identifier.wosWOS:000362282000002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKızıler, Ali Rıza
dc.institutionauthorGüzel, Savaş
dc.institutionauthorAcar, Ayşe
dc.institutionauthorYazıcı, Cenk Murat
dc.language.isoen
dc.publisherHumana Press Inc
dc.relation.ispartofBiological Trace Element Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectVaricocele
dc.subjectMalondialdehyde
dc.subjectNitric oxide
dc.subjectAsymmetric dimethylarginine
dc.subjectSemen analysis
dc.subjectCopper
dc.subjectZinc
dc.subjectIron
dc.subjectOxidative Stress
dc.subjectInfertile Men
dc.subjectSemen
dc.subjectAntioxidants
dc.subjectPathogenesis
dc.titleComparison of Before and After Varicocelectomy Levels of Trace Elements, Nitric Oxide, Asymmetric Dimethylarginine and Malondialdehyde in the Seminal Plasma and Peripheral and Spermatic Veins
dc.typeArticle

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