The role of novel cytokines in inflammation: Defining peripheral artery disease among patients with coronary artery disease

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dc.authorscopusid55317577700
dc.authorscopusid23968920100
dc.authorscopusid16315021800
dc.authorscopusid6505680586
dc.authorscopusid7005837198
dc.authorwosidAlpsoy, Seref/Z-1808-2018
dc.contributor.authorÖzkaramanlı Gür, Demet
dc.contributor.authorGüzel, Savaş
dc.contributor.authorAkyüz, Aydın
dc.contributor.authorAlpsoy, Şeref
dc.contributor.authorGüler, Niyazi
dc.date.accessioned2022-05-11T14:40:09Z
dc.date.available2022-05-11T14:40:09Z
dc.date.issued2018
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.description.abstractCoronary artery disease (CAD) patients with concomitant peripheral artery disease (PAD) experience more extensive and calcified atherosclerosis, greater lesion progression and more common coronary events compared to patients with CAD only. To characterize the distinct features of this aggressive atherosclerotic disease, we studied novel cytokines that code different stages of atherogenesis. One hundred and eighty consecutive subjects (60 patients into each group of CAD+PAD, CAD and controls) were recruited among patients with stable angina pectoris scheduled for coronary angiography. An ankle-brachial index (ABI) 0.9 was determined as occlusive PAD. Fasting serum tumor necrosis factor (TNF)-like antigen 1A (TL1A) and its receptor death receptor 3 (DR3), NOGO-B (reticulon 4B) and its receptor NUS1, high-sensitivity C-reactive protein (hsCRP), A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) 1, 4, 5 and interleukin (IL) 6 levels were determined. Serum hsCRP and DR3/TL1A concentrations were similar and higher than controls in the CAD and CAD+PAD groups. Levels of NOGO-B and its receptor NUS1 were increased and ADAMTS-5 was decreased in patients with CAD+PAD. Independent predictors of ABI in multivariate analysis were smoking (B = -0.13, p = 0.04), NUS1 (B = -0.88, p < 0.001), ADAMTS-5 (B = 0.63, p < 0.001) and SYNTAX score (B = -0.26, p < 0.001). Similarly, smoking (OR = 5.5, p = 0.019), SYNTAX score (OR = 1.2, p < 0.001), NUS1 (OR = 14.4, p < 0.001), ADAMTS-5 (OR = 1.1, p < 0.001) and age (OR = 1.1, p = 0.042) independently predicted the involvement of peripheral vasculature in logistic regression. The diagnostic performance of these cytokines to discriminate CAD+PAD were AUC 0.79 (p < 0.001) for NUS1 and 0.37 (p = 0.013) for ADAMTS-5. We report herein that circulating cytokines can give clues to the ongoing atherosclerotic process and the extent of vascular involvement in which distinct features of ADAMTS-5 and NUS1 make them promising cytokines for future research.
dc.description.sponsorshipScientific Research Projects Council of Namik Kemal University [NKUBAP.02.GA.16.044]
dc.description.sponsorshipThe authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Scientific Research Projects Council of Namik Kemal University (NKUBAP.02.GA.16.044).
dc.identifier.doi10.1177/1358863X18763096
dc.identifier.endpage436
dc.identifier.issn1358-863X
dc.identifier.issn1477-0377
dc.identifier.issue5en_US
dc.identifier.pmid29638194
dc.identifier.scopus2-s2.0-85045270211
dc.identifier.scopusqualityQ2
dc.identifier.startpage428
dc.identifier.urihttps://doi.org/10.1177/1358863X18763096
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8883
dc.identifier.volume23
dc.identifier.wosWOS:000443965700003
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖzkaramanlı Gür, Demet
dc.institutionauthorGüzel, Savaş
dc.institutionauthorAkyüz, Aydın
dc.institutionauthorAlpsoy, Şeref
dc.institutionauthorGüler, Niyazi
dc.language.isoen
dc.publisherSage Publications Ltd
dc.relation.ispartofVascular Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectADAMTS-5
dc.subjectcoronary artery disease
dc.subjectNUS1
dc.subjectperipheral artery disease (PAD)
dc.subjectReceptor Family-Member
dc.subjectNogo-B
dc.subjectAtherosclerosis
dc.subjectProgression
dc.subjectExpression
dc.subjectDeath
dc.subjectTl1a
dc.subjectDr3
dc.titleThe role of novel cytokines in inflammation: Defining peripheral artery disease among patients with coronary artery disease
dc.typeArticle

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