Microbiologic, Pharmacokinetic, and Clinical Effects of Corneal Collagen Cross-Linking on Experimentally Induced Pseudomonas Keratitis in Rabbits

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dc.authorid0000-0002-1455-4931
dc.authorid0000-0002-6113-661X
dc.authorid0000-0003-1115-0429
dc.authorid0000-0002-4018-9798
dc.authorid0000-0001-7868-7613
dc.authorscopusid6603443273
dc.authorscopusid7004277869
dc.authorscopusid56868309300
dc.authorscopusid34869701000
dc.authorscopusid26038972000
dc.authorscopusid6701785786
dc.authorscopusid6504553678
dc.authorwosidÇelik, Ekrem/AAD-1802-2022
dc.authorwosidince, ümit/T-8783-2017
dc.authorwosidCosar, Cemile B/D-6634-2016
dc.authorwosidakyar, ışın/D-3362-2015
dc.authorwosidAkyar, Isin/D-7950-2017
dc.authorwosidSerteser, Mustafa/F-9130-2015
dc.contributor.authorCoşar, Cemile Banu
dc.contributor.authorKücük, Mutlu
dc.contributor.authorÇelik, Ekrem
dc.contributor.authorGönen, Tansu
dc.contributor.authorAkyar, Işın
dc.contributor.authorSerteser, Mustafa
dc.contributor.authorİnce, Umit
dc.date.accessioned2022-05-11T14:35:46Z
dc.date.available2022-05-11T14:35:46Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göz Hastalıkları Ana Bilim Dalı
dc.description.abstractPurpose: To determine the effects of corneal collagen cross-linking (CXL) on the penetration of topical 0.5% moxifloxacin, on the number of colony-forming units (CFUs) in the cornea, and on the clinical course in a rabbit eye model of experimentally induced Pseudomonas aeruginosa keratitis. Methods: In this prospective animal study, experimental Pseudomonas corneal ulcers were induced in 56 corneas of 28 albino New Zealand rabbits. The corneas were randomly divided into the following 4 groups: the control group (14 eyes), the MOX group (moxifloxacin) (14 eyes), the MOX + CXL group (14 eyes), and the CXL group (14 eyes). On day 4 of the experiment, the eyes in the control group were enucleated and CFU counting was performed. On day 10 of the experiment, all eyes were enucleated and CFU counting was performed. In the MOX and MOX + CXL groups, the moxifloxacin level in the cornea, aqueous humor, iris, plasma, and serum was measured by reverse-phase high-performance liquid chromatography. Results: The difference in the corneal CFU count between the MOX group and the MOX + CXL group was not significant (P = 0.317). Clinical improvement was greatest in the MOX + CXL group (P, 0.001). The mean corneal moxifloxacin level was 0.391 +/- 0.09 mu g.mg(-1) in the MOX group versus 0.291 +/- 0.09 mu g.mg(-1) in the MOX + CXL group; as such, CXL did not have a significant effect on antibiotic penetrance (P = 0.386). Conclusions: Clinical improvement was greatest in the MOX + CXL group. The synergistic effect of CXL on corneal ulcer treatment is not through antibiotic penetrance.
dc.description.sponsorshipTUBITAK (The Scientific and Technological Research Council of Turkey)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK)
dc.description.sponsorshipSupported by TUBITAK (The Scientific and Technological Research Council of Turkey).
dc.identifier.doi10.1097/ICO.0000000000000516
dc.identifier.endpage1280
dc.identifier.issn0277-3740
dc.identifier.issn1536-4798
dc.identifier.issue10en_US
dc.identifier.pmid26226468
dc.identifier.scopus2-s2.0-84942257034
dc.identifier.scopusqualityQ1
dc.identifier.startpage1276
dc.identifier.urihttps://doi.org/10.1097/ICO.0000000000000516
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8212
dc.identifier.volume34
dc.identifier.wosWOS:000361533500016
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÇelik, Ekrem
dc.institutionauthorGönen, Tansu
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofCornea
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPseudomonas corneal ulcer
dc.subjectmicrobial keratitis
dc.subjectexperimental keratitis
dc.subjectcross-linking
dc.subjectmoxifloxacine
dc.subjectInfectious Keratitis
dc.subjectPack-Cxl
dc.subjectRiboflavin
dc.subjectEfficacy
dc.subjectPermeability
dc.subjectPenetration
dc.subjectBacterial
dc.subjectTherapy
dc.titleMicrobiologic, Pharmacokinetic, and Clinical Effects of Corneal Collagen Cross-Linking on Experimentally Induced Pseudomonas Keratitis in Rabbits
dc.typeArticle

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