LOX-1 gene variants and maternal levels of plasma oxidized LDL and malondialdehyde in patients with gestational diabetes mellitus

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dc.authorid0000-0002-9754-8456
dc.authorid0000-0002-9634-3651
dc.authorid0000-0002-1347-8498
dc.authorid0000-0002-8495-6426
dc.authorid0000-0002-8497-4704
dc.authorscopusid8713588200
dc.authorscopusid10241165400
dc.authorscopusid56563019100
dc.authorscopusid23667114900
dc.authorscopusid16744840400
dc.authorscopusid6508166517
dc.authorscopusid26657105600
dc.authorwosidBaykara, Onur/V-5990-2018
dc.authorwosidErkorkmaz, Ünal/AAA-4241-2022
dc.authorwosidTüten, Abdullah/E-2856-2019
dc.authorwosidCinemre, Hakan/AAD-7506-2021
dc.authorwosidoncul, mahmut/AAC-9278-2021
dc.authorwosidUzun, Hafize/D-4811-2019
dc.authorwosidErkorkmaz, Unal/B-1270-2016
dc.contributor.authorAydemir, Birsen
dc.contributor.authorBaykara, Onur
dc.contributor.authorCinemre, Fatma Behice Serinkan
dc.contributor.authorCinemre, Hakan
dc.contributor.authorTüten, Abdullah
dc.contributor.authorKızıler, Ali Rıza
dc.contributor.authorUzun, Hafize
dc.date.accessioned2022-05-11T14:41:21Z
dc.date.available2022-05-11T14:41:21Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.description.abstractPurpose The aim of this study was to investigate the relationships between the maternal levels of oxidized LDL (ox-LDL), lipid peroxidation marker malondialdehyde (MDA) and LOX-1 3'UTR188C/T and K167N single nucleotide polymorphisms in pregnant Turkish women with gestational diabetes mellitus (GDM). Methods 116 pregnant women with GDM and 120 healthy pregnant women from the same geographic region were included in the study. Polymerase chain reaction-based restriction analysis was used to identify 3'UTR188C/T and K167N polymorphisms of the LOX-1 gene. Plasma ox-LDL and MDA levels were determined by enzyme-linked immunosorbent assay and spectrophotometric method in all study subjects, respectively. Results Our results indicated that the distribution of the LOX-1 3'UTR188C/T and K167N genotypes and alleles did not differ significantly among subjects with or without GDM (p> 0.05). TT and NN genotype carriers are associated with some glucose metabolism parameters (p< 0.05). There were no significant differences among plasma ox-LDL and MDA levels with regard to LOX-1 3'UTR188C/T and K167N polymorphisms in GDM group and control subjects (p> 0.05). According to the combined genotype analysis of LOX-1 3'UTR 188 TT and K167N NN polymorphisms, plasma MDA and ox-LDL levels were significantly different between women with GDM and healthy subjects either with or without combined TT/NN genotype carriers (p< 0.001). Conclusions According to our results, ox-LDL and MDA levels were increased in GDM pregnant women and healthy pregnant women either with or without combined TT/NN genotype carriers, for our Turkish sample, these genotype carriers appear to be related with increased oxidative stress in patients with GDM.
dc.identifier.doi10.1007/s00404-015-3851-6
dc.identifier.endpage527
dc.identifier.issn0932-0067
dc.identifier.issn1432-0711
dc.identifier.issue3en_US
dc.identifier.pmid26296941
dc.identifier.scopus2-s2.0-84958757860
dc.identifier.scopusqualityQ2
dc.identifier.startpage517
dc.identifier.urihttps://doi.org/10.1007/s00404-015-3851-6
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9156
dc.identifier.volume293
dc.identifier.wosWOS:000372601200006
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKızıler, Ali Rıza
dc.language.isoen
dc.publisherSpringer Heidelberg
dc.relation.ispartofArchives of Gynecology and Obstetrics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectGestational diabetes mellitus
dc.subjectOxidized LDL
dc.subjectMalondialdehyde
dc.subjectLectin-like oxidized LDL receptor-1 gene polymorphism
dc.subjectLow-Density-Lipoprotein
dc.subjectHuman Lectin-Like
dc.subjectOlr1 Gene
dc.subjectReceptor-1
dc.subjectPolymorphism
dc.subjectAssociation
dc.subjectExpression
dc.subjectRisk
dc.subjectAdhesion
dc.subjectBinding
dc.titleLOX-1 gene variants and maternal levels of plasma oxidized LDL and malondialdehyde in patients with gestational diabetes mellitus
dc.typeArticle

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