Asymmetric dimethylarginine contributes to airway nitric oxide deficiency in patients with COPD

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dc.authorid0000-0002-3535-5704
dc.authorid0000-0002-4852-7915
dc.authorscopusid7102765266
dc.authorscopusid54892706700
dc.authorscopusid8531050000
dc.authorscopusid56715752200
dc.authorscopusid55881189500
dc.authorscopusid8514414100
dc.authorscopusid37058172000
dc.authorwosidTAYFUR, İsmail/S-2208-2017
dc.authorwosidBilir, Bülent/AAK-5656-2021
dc.authorwosidMutlu, Levent Cem/AAZ-5186-2020
dc.contributor.authorAydın, Murat
dc.contributor.authorAltıntaş, Nejat
dc.contributor.authorMutlu, Levent Cem
dc.contributor.authorBilir, Bülent
dc.contributor.authorOran, Mustafa
dc.contributor.authorTülübaş, Feti
dc.contributor.authorGürel, Ahmet
dc.date.accessioned2022-05-11T14:07:45Z
dc.date.available2022-05-11T14:07:45Z
dc.date.issued2017
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.description.abstractIntroductionAsymmetric dimethylarginine (ADMA) and nitric oxide (NO) show their mechanism of action reciprocally, the balance between these molecules contributes to the tight regulation of airways tone and function. ObjectivesThe aim of this study to determine the serum levels of ADMA and NO in patients with chronic obstructive pulmonary disease (COPD) and establish whether their level vary in relation to forced expiratory volume in 1s (FEV1), to assess their role in pathophysiology of COPD. Materials and MethodsThis study consisted of 58 patients with COPD and 30 healthy subjects. Serum ADMA and NO levels were measured using enzyme-linked immunosorbent assay and the colorimetric method, respectively. ResultsSerum ADMA levels were significantly higher, however, NO levels were lower in patients with COPD compared with controls. ADMA levels were inversely correlated with NO levels. Serum ADMA and NO were significantly correlated with FEV1. Multivariable logistic regression analysis revealed that serum ADMA and NO were independently and significantly associated with the presence of COPD. Multiple linear regression analysis showed that COPD was positively associated with ADMA, additionally COPD and ADMA were independently and inversely associated with NO. NO levels were decreased, ADMA levels were increased compliant with progression of COPD stages. ConclusionWhile circulating ADMA is higher, NO is lower in COPD and both show a strong correlation to the degree of airflow limitation. ADMA seems to be a possible new marker of prognosis of COPD and can be a novel therapeutic target for the treatment of COPD.
dc.identifier.doi10.1111/crj.12337
dc.identifier.endpage327
dc.identifier.issn1752-6981
dc.identifier.issn1752-699X
dc.identifier.issue3en_US
dc.identifier.pmid26076870
dc.identifier.scopus2-s2.0-84937509307
dc.identifier.scopusqualityQ3
dc.identifier.startpage318
dc.identifier.urihttps://doi.org/10.1111/crj.12337
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5190
dc.identifier.volume11
dc.identifier.wosWOS:000400580500006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAydın, Murat
dc.institutionauthorAltıntaş, Nejat
dc.institutionauthorMutlu, Levent Cem
dc.institutionauthorBilir, Bülent
dc.institutionauthorOran, Mustafa
dc.institutionauthorTülübaş, Feti
dc.institutionauthorGürel, Ahmet
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofClinical Respiratory Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectasymmetric dimethylarginine
dc.subjectchronic obstructive pulmonary disease
dc.subjectnitric oxide
dc.subjectpulmonary function test
dc.subjectObstructive Pulmonary-Disease
dc.subjectLung-Function
dc.subjectArginase-I
dc.subjectEndothelial Dysfunction
dc.subjectSystemic Inflammation
dc.subjectOxidative Stress
dc.subjectHeart-Disease
dc.subjectL-Arginine
dc.subjectAdma
dc.subjectAsthma
dc.titleAsymmetric dimethylarginine contributes to airway nitric oxide deficiency in patients with COPD
dc.typeArticle

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