Calcitonin Gene Related Peptide Gene Polymorphism in Migraine Patients

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dc.authorid0000-0001-6033-7148
dc.authorid0000-0002-9006-1880
dc.authorwosidunlu, ayhan/Q-1843-2016
dc.authorwosidyamasan, bilge eren/I-8363-2017
dc.contributor.authorGüldiken, Babürhan Feyzullah
dc.contributor.authorSipahi, Tammam
dc.contributor.authorTekinarslan, Remziye
dc.contributor.authorKabayel, Levent
dc.contributor.authorÖzkan, Hülya
dc.contributor.authorÜnlü, Ayhan
dc.contributor.authorTurgut, Nilda
dc.date.accessioned2022-05-11T14:40:14Z
dc.date.available2022-05-11T14:40:14Z
dc.date.issued2013
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractObjective: Calcitonin gene related peptide (CGRP), which has a vasodilator effect, is held responsible for neurogenic inflammation and vasodilatation of the cranial vessels in migraine pathophysiology. In this study, we investigated the association between alpha CGRP gene polymorphism (CALCA T-692C) and migraine. Material and Methods: One hundred and thirty-four female migraineurs and 96 healthy female cases were enrolled in the study. The patient group was further subdivided into migraine with and without aura groups. The CALCA T-692C gene polymorphism was identified using polymerase chain reaction (PCR) technique and restriction fragment length polymorphism (RFLP). Results: The genotype and allele frequencies of CALCA T-692C gene polymorphism did not differ between the migraine and control groups. Between the migraine with and without aura subgroups, there was no difference. No association was seen between the CALCA T-692C gene polymorphisms and migraine attack severity and frequency. Conclusion: Our study did not show any association between CALCA T-692C gene polymorphism and migraine.
dc.identifier.doi10.1017/S0317167100014980
dc.identifier.endpage725
dc.identifier.issn0317-1671
dc.identifier.issn2057-0155
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-84883256843
dc.identifier.scopusqualityQ2
dc.identifier.startpage722
dc.identifier.urihttps://doi.org/10.1017/S0317167100014980
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8911
dc.identifier.volume40
dc.identifier.wosWOS:000326200400018
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorTurgut, Nilda
dc.language.isoen
dc.publisherCambridge Univ Press
dc.relation.ispartofCanadian Journal of Neurological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCgrp
dc.titleCalcitonin Gene Related Peptide Gene Polymorphism in Migraine Patients
dc.typeArticle

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