Airway inflammatory markers in chronic obstructive pulmonary disease patients and healthy smokers

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dc.authorid0000-0002-3535-5704
dc.authorid0000-0002-2572-1870
dc.authorscopusid6507965905
dc.authorscopusid8531050000
dc.authorscopusid6602609706
dc.authorwosidMutlu, Levent Cem/AAZ-5186-2020
dc.authorwosidHacievliyagil, Suleyman Savas/ABI-7307-2020
dc.contributor.authorHacievliyagil, S. S.
dc.contributor.authorMutlu, Levent Cem
dc.contributor.authorTemel, İlkbal
dc.date.accessioned2022-05-11T14:39:46Z
dc.date.available2022-05-11T14:39:46Z
dc.date.issued2013
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground: Cigarette smoke with its toxic ingredients leads to chronic inflammations in the airways. Objectives: In this study, the effect of cigarette smoke on the levels of inflammatory markers, interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor-alpha (TNF-) in induced sputum was investigated. Materials and Methods: Twenty patients with chronic obstructive pulmonary disease (COPD) (group I), 20 healthy smokers (group II), and 20 healthy nonsmokers (group III) were included in the study. The levels of IL-6, IL-8, and TNF- in induced sputum were measured in these groups, and comparison analysis between the groups and correlation analysis for smoking load (pack-years) and spirometric parameters were performed. Results: Mean age of the patients in groups I, II, and III were 61.2 1.7, 58.2 1.6, and 59.1 5.4 years, respectively (P > 0.05). Smoking loads of group I and group II were 38.6 2.1 and 29.5 2.3 pack-years, respectively (P < 0.05). All cytokine levels were significantly higher in group I than groups II and III (P < 0.05). In addition to this, mean cytokines levels were significantly higher in group II than group III (P < 0.05). Smoking load of group II subjects was positively correlated with IL-6, IL-8, and TNF- in induced sputum (P < 0.05). Conclusions: We found that inflammatory marker levels in induced sputum were significantly higher in COPD patients and smokers than nonsmokers. Moreover, there was a moderate positive correlation between IL-6, IL-8, and TNF- levels and smoking load in the healthy smokers. We think that further studies are needed to determine whether higher levels of cytokine levels in sputum might be helpful in predicting the healthy smokers who will develop COPD in future.
dc.identifier.doi10.4103/1119-3077.106771
dc.identifier.endpage81
dc.identifier.issn1119-3077
dc.identifier.issue1en_US
dc.identifier.pmid23377476
dc.identifier.scopus2-s2.0-84873669995
dc.identifier.scopusqualityQ3
dc.identifier.startpage76
dc.identifier.urihttps://doi.org/10.4103/1119-3077.106771
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8716
dc.identifier.volume16
dc.identifier.wosWOS:000316363600017
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorMutlu, Levent Cem
dc.language.isoen
dc.publisherMedknow Publications & Media Pvt Ltd
dc.relation.ispartofNigerian Journal of Clinical Practice
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectChronic obstructive pulmonary disease
dc.subjectinflammatory markers
dc.subjectinduced sputum
dc.subjectIL-6
dc.subjectIL-8
dc.subjectTNF-alpha
dc.subjectInduced Sputum
dc.subjectEpithelial-Cells
dc.subjectInterleukin-8
dc.subjectExacerbations
dc.subjectRelease
dc.subjectAsthma
dc.titleAirway inflammatory markers in chronic obstructive pulmonary disease patients and healthy smokers
dc.typeArticle

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