Chronic administration of imipramine but not agomelatine and moclobemide affects the nitrergic relaxation of rabbit corpus cavernosum smooth muscle

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dc.authorid0000-0001-7341-4907
dc.authorid0000-0001-5848-3680
dc.authorscopusid11440747800
dc.authorscopusid7003362092
dc.authorscopusid6603418006
dc.authorwosidgocmez, semil selcen/G-2401-2018
dc.authorwosidUtkan, Tijen/G-2398-2018
dc.contributor.authorGöçmez, Semil Selcen
dc.contributor.authorUtkan, Tijen
dc.contributor.authorGacar, Nejat
dc.date.accessioned2022-05-11T14:41:10Z
dc.date.available2022-05-11T14:41:10Z
dc.date.issued2013
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.description.abstractSexual dysfunction is a common and underestimated effect of antidepressants. However, the mechanism by which these drugs cause erectile dysfunction is unclear. We investigated the reactivity of the corpus cavernosum of rabbits that were treated with either chronic imipramine, which is a tricyclic agent; agomelatine, which is a melatonergic agonist and serotonin 5HT(2c) antagonist; or moclobemide, which is a reversible inhibitor of monoamine-oxidase A. Twenty rabbits were randomly divided into four groups: the control group (n = 5), the imipramine-treated group (n = 5), which received i.p. injections of 10 mg/kg/day of imipramine, the moclobemide-treated group (n = 5), which received i.p injections of 20 mg/kg/day of moclobemide, and the agomelatine-treated group (n = 5), which was orally administered 10 mg/kg/day of agomelatine. The reactivities of corpus cavernosum tissue obtained from the antidepressant-treated and the control groups were studied in organ chambers after the animals were subjected to 21 days of drug administration. The acetylcholine-induced endothelium-dependent and the electrical field stimulation (EFS)-induced neurogenic relaxation of the corpus cavernosum of the imipramine-treated group was significantly decreased compared with the control group. However, neither the acetylcholine- nor EFS-induced relaxation was changed in the moclobemide- or agomelatine-treated groups. There were no change in the relaxant response to the nitric oxide (NO) donor sodium nitroprusside and contractile response to KCl between the groups. This study suggests that chronic imipramine treatment but not agomelatine and moclobemide treatments causes significant functional changes in the penile erectile tissue of rabbits and that these changes may contribute to the development of impotence. (c) 2013 Elsevier B.V. All rights reserved.
dc.identifier.doi10.1016/j.ejphar.2013.07.003
dc.identifier.endpage447
dc.identifier.issn0014-2999
dc.identifier.issn1879-0712
dc.identifier.issue45352en_US
dc.identifier.pmid23845214
dc.identifier.scopus2-s2.0-84885469409
dc.identifier.scopusqualityQ1
dc.identifier.startpage442
dc.identifier.urihttps://doi.org/10.1016/j.ejphar.2013.07.003
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9092
dc.identifier.volume714
dc.identifier.wosWOS:000323601100057
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGöçmez, Semil Selcen
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofEuropean Journal of Pharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPenis
dc.subjectCorpus cavernosum
dc.subjectImipramine
dc.subjectAgomelatine
dc.subjectMoclobemide
dc.subjectErectile dysfunction
dc.subjectSerotonin Reuptake Inhibitors
dc.subjectMajor Depressive Disorder
dc.subjectNitric-Oxide Synthase
dc.subjectSexual Dysfunction
dc.subjectDouble-Blind
dc.subjectResponses
dc.subjectPlacebo
dc.subjectAntidepressants
dc.subjectVenlafaxine
dc.subjectFluoxetine
dc.titleChronic administration of imipramine but not agomelatine and moclobemide affects the nitrergic relaxation of rabbit corpus cavernosum smooth muscle
dc.typeArticle

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