The effect of telmisartan, an angiotensin receptor blocker, on alcohol consumption and alcohol-induced dopamine release in the nucleus accumbens

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dc.contributor.authorTezcan, Kutluhan
dc.contributor.authorYananli, Hasan Raci
dc.contributor.authorDemirkapu, Mahluga Jafarova
dc.contributor.authorGören, M. Zafer
dc.contributor.authorSakalli, H. Eren
dc.contributor.authorColombo, Giancarlo
dc.contributor.authorGülhan, Rezzan
dc.date.accessioned2024-10-29T17:43:27Z
dc.date.available2024-10-29T17:43:27Z
dc.date.issued2021
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractAlcohol use disorder remains a major health problem. The mesocorticolimbic dopaminergic system, including the nucleus accumbens region and multiple neural circuits, is involved in its complex underlying mechanism. For instance, alcohol intake stimulates the central and peripheral renin-angiotensin system and increases angiotensin II levels, which predominantly affect angiotensin 1 receptors both in the periphery and in the brain. In this study, we aimed to investigate the effects of the intracerebroventricularly-administered angiotensin 1 receptor blocker telmisartan on the alcohol consumption of male Sardinian alcohol-preferring (sP) rats and on the alcohol-induced dopamine levels in the nucleus accumbens region in Wistar rats. Acute intracerebroventricular administration of telmisartan (100 nM) reduced the alcohol intake for 24 hours without affecting food and water consumption in sP rats. Acute intracerebroventricular injection of the opioid receptor antagonist naloxone (75 nM), tested as a reference compound, also reduced the alcohol consumption in sP rats; however, naloxone's effect lasted only for 30 minutes. In microdialysis experiments, telmisartan administered intracerebroventricularly did not change dopamine levels in the nucleus accumbens that had been induced by acute intraperitoneal alcohol administration in Wistar rats. According to these results, further studies are needed to elucidate the role of the renin-angiotensin system on alcohol use disorder pathophysiology. © 2021 Elsevier Inc.
dc.description.sponsorshipMarmara Üniversitesi, (SAG-C-TUP-031210-0269)
dc.identifier.doi10.1016/j.alcohol.2021.08.004
dc.identifier.endpage81
dc.identifier.issn0741-8329
dc.identifier.pmid34419631
dc.identifier.scopus2-s2.0-85115344288
dc.identifier.scopusqualityQ2
dc.identifier.startpage73
dc.identifier.urihttps://doi.org/10.1016/j.alcohol.2021.08.004
dc.identifier.urihttps://hdl.handle.net/20.500.11776/12382
dc.identifier.volume96
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Inc.
dc.relation.ispartofAlcohol
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAlcohol
dc.subjectAngiotensin receptor blocker
dc.subjectDopamine
dc.subjectNucleus accumbens
dc.subjectSardinian alcohol-preferring (sP) rat
dc.subjectTwo-bottle free choice paradigm
dc.titleThe effect of telmisartan, an angiotensin receptor blocker, on alcohol consumption and alcohol-induced dopamine release in the nucleus accumbens
dc.typeArticle

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