Protective effects of thymoquinone on experimental testicular ischaemia-reperfusion injury: an apoptotic, proliferative and biochemical study

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dc.authorscopusid36023238400
dc.authorscopusid24436194200
dc.authorscopusid57216014831
dc.authorscopusid26434076100
dc.authorscopusid25647609500
dc.authorscopusid56414492000
dc.authorscopusid37058172000
dc.authorwosidAktas, Cevat/D-8468-2011
dc.contributor.authorErboğa, Mustafa
dc.contributor.authorAktaş, C.
dc.contributor.authorKurt, Ömer
dc.contributor.authorUygur, Ramazan
dc.contributor.authorÇağlar, Veli
dc.contributor.authorTuran, Bünyamin Cüneyt
dc.contributor.authorÖzen, Oğuz Aslan
dc.date.accessioned2022-05-11T14:07:32Z
dc.date.available2022-05-11T14:07:32Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Anatomi Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Anesteziyoloji ve Reanimasyon Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractThe objective of this study was to examine the effects of thymoquinone (TQ), which has antioxidant properties in the experimental testicular I/R model in rats in terms of its anti-apoptotic, proliferative and biochemical attributes. In our study, 24 male rats were divided into three groups: control group, I/R group and I/R+TQ group. Testicular torsion was created by rotating the left testis 720 degrees in a clockwise direction. The ischaemia period was 4h, and an orchiectomy was performed after 4h of detorsion. Spermatogenesis and the mean seminiferous tubule diameter were significantly decreased in the I/R groups compared to the control group. Furthermore, TQ-treated animals displayed an improved histological appearance in the I/R group. It was also observed that treatment with TQ increased the activity of PCNA, which decreased as a result of I/R, and this treatment also reduced the number of TUNEL-positive cells. The I/R+TQ group showed a decrease in malondialdehyde levels and an increase in the activities of superoxide dismutase, catalase and glutathione peroxidase in comparison with the I/R group. It could be concluded that cytoprotective effects of TQ on the I/R testicles are via reduction of apoptosis, oxidative stress and lipid peroxidation.
dc.description.sponsorshipNamik Kemal University Research Center, Tekirdag, TurkeyNamik Kemal University [NKU-BAP.00.20.AR.13.05]
dc.description.sponsorshipThis study was supported under Project NKU-BAP.00.20.AR.13.05 by the Namik Kemal University Research Center, Tekirdag, Turkey.
dc.identifier.doi10.1111/and.12436
dc.identifier.endpage230
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue2en_US
dc.identifier.pmid26011095
dc.identifier.scopus2-s2.0-84957441056
dc.identifier.scopusqualityQ2
dc.identifier.startpage222
dc.identifier.urihttps://doi.org/10.1111/and.12436
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5138
dc.identifier.volume48
dc.identifier.wosWOS:000370224300013
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorErboğa, Mustafa
dc.institutionauthorAktaş, C.
dc.institutionauthorKurt, Ömer
dc.institutionauthorUygur, Ramazan
dc.institutionauthorÇağlar, Veli
dc.institutionauthorTuran, Bünyamin Cüneyt
dc.institutionauthorÖzen, Oğuz Aslan
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofAndrologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectApoptosis
dc.subjectischaemia and reperfusion
dc.subjectoxidative stress
dc.subjecttestis
dc.subjectthymoquinone
dc.subjectLipid-Peroxidation
dc.subjectSeminiferous Tubules
dc.subjectChronic Ethanol
dc.subjectRat
dc.subjectMelatonin
dc.subjectTorsion
dc.subjectTestis
dc.subjectDamage
dc.subjectDeath
dc.titleProtective effects of thymoquinone on experimental testicular ischaemia-reperfusion injury: an apoptotic, proliferative and biochemical study
dc.typeArticle

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