The diagnostic value of late-night salivary cortisol for diagnosis of subclinical Cushing's syndrome

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dc.authorid0000-0001-5584-4954
dc.authorid0000-0001-8084-848X
dc.authorscopusid55753696900
dc.authorscopusid36656843500
dc.authorscopusid56419558300
dc.authorscopusid57191893635
dc.authorscopusid36926020100
dc.authorscopusid35517398400
dc.authorwosidÖztürk, Feyza Yener/AAL-3013-2020
dc.authorwosidZuhur, Sayid/AAC-6839-2020
dc.contributor.authorKuzu, İdris
dc.contributor.authorZuhur, Sayid Shafi
dc.contributor.authorDemir, Nazan
dc.contributor.authorAktaş, Gökce
dc.contributor.authorÖztürk, Feyza Yener
dc.contributor.authorAltuntaş, Yüksel
dc.date.accessioned2022-05-11T14:39:55Z
dc.date.available2022-05-11T14:39:55Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractIntroduction: Late-night salivary cortisol is a frequently used and easily implemented diagnostically valuable test for the diagnosis of overt Cushing's syndrome. The use of late-night salivary cortisol in the diagnosis of subclinical Cushing's syndrome is somewhat controversial. In this study, we aimed to determine the diagnostic value of late-night salivary cortisol in diagnosing subclinical Cushing's syndrome and compare it with 24-hour urinary free cortisol levels (UFC). Material and methods: The study consisted of 33 cases of subclinical Cushing's syndrome, 59 cases of non-functioning adrenal adenoma, and 41 control subjects. Late-night salivary cortisol and UFC were measured in all the cases. The diagnosis of subclinical Cushing's syndrome was based on combined results of 1 mg dexamethasone suppression test > 1.8 mu g/dL and ACTH < 10 pg/mL. Results: Mean late-night salivary cortisol levels in subjects with subclinical Cushing's syndrome were significantly higher than in subjects with non-functioning adrenal adenoma and the control group (p < 0.001). Using a cut-off value of 0.18 mu g/dL, the sensitivity and specificity of late-night salivary cortisol for diagnosing subclinical Cushing's syndrome were determined as 82% and 60%, respectively. Using a cut-off value of 137 mu g/day, the sensitivity and specificity of UFC was determined as 18% and 90%, respectively. Conclusions: Because the sensitivity of late-night salivary cortisol for the diagnosis of subclinical Cushing's syndrome is limited, using it as the sole screening test for subclinical Cushing's syndrome may lead to false negative results. However, using it as an adjunct test to other tests may be beneficial in the diagnosis of subclinical Cushing's syndrome.
dc.identifier.doi10.5603/EP.a2016.0028
dc.identifier.endpage492
dc.identifier.issn0423-104X
dc.identifier.issue5en_US
dc.identifier.pmid26884297
dc.identifier.scopus2-s2.0-84994607791
dc.identifier.scopusqualityQ3
dc.identifier.startpage487
dc.identifier.urihttps://doi.org/10.5603/EP.a2016.0028
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8793
dc.identifier.volume67
dc.identifier.wosWOS:000392136100003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorZuhur, Sayid Shafi
dc.language.isoen
dc.publisherVia Medica
dc.relation.ispartofEndokrynologia Polska
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectsubclinical Cushing's syndrome
dc.subjectsalivary cortisol
dc.subjecturinary free cortisol
dc.subjectscreening
dc.subjectAdrenal Incidentaloma
dc.subjectSerum
dc.subjectHypercortisolism
dc.subjectPerformance
dc.subjectManagement
dc.subjectSociety
dc.subjectOvert
dc.titleThe diagnostic value of late-night salivary cortisol for diagnosis of subclinical Cushing's syndrome
dc.typeArticle

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