Changes in expression of Slit1 and its receptor Robo2 in trigeminal ganglion and inferior alveolar nerve following inferior alveolar nerve axotomy in adult rats: a pilot study

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dc.authorid0000-0003-0827-2708
dc.authorscopusid14630077000
dc.authorscopusid24074751600
dc.authorscopusid55885900400
dc.authorscopusid55515412500
dc.authorscopusid16023358200
dc.authorscopusid57191410126
dc.authorscopusid8514414100
dc.authorwosidsener, umit/AAZ-7728-2020
dc.authorwosiddurak, mehmet akif/ABI-1169-2020
dc.contributor.authorCeber, Mehmet
dc.contributor.authorMihmanli, Ahmet
dc.contributor.authorKılıç, Ulkan
dc.contributor.authorŞener, Ümit
dc.contributor.authorYüksek, A.
dc.contributor.authorDurak, M. A.
dc.contributor.authorTülübaş, Feti
dc.date.accessioned2022-05-11T14:07:37Z
dc.date.available2022-05-11T14:07:37Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Plastik, Rekonstrüktif ve Estetik Cerrahi Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Anesteziyoloji ve Reanimasyon Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractThe objective of this study was to analyze changes in expression pattern of Slit1 and Robo2, and to clarify the relationship between these changes and functional recovery of the axotomized inferior alveolar nerve (IAN) without repair using a rat IAN axotomy model. Slitl and Robo2 were weakly expressed in samples taken from trigeminal ganglion (TG) and IAN of sham surgery rats. In axotomized rats, expression levels increased significantly from day 2 to day 28 post-axotomy, with peaks on days 14 (Slit1) and 7 (Robo2) after axotomy (relative to sham: Slit1 in TG P < 0.0005, Slitl in IAN P = 0.003, Robo2 in TG P < 0.0005, and Robo2 in IAN P < 0.0005). Over-expressed Slitl and Robo2 in both the TG and IANs of axotomized rats did not return to sham levels during the 28-day observation period of this study. The regeneration and functional recovery of axotomized IAN was evaluated by jaw opening reflex (JOR) recorded before and after axotomy. JOR occurrence (0% on day 7, 35% on day 14, and 85% on day 28) increased gradually, and the relative threshold of electrical stimulation eliciting JOR decreased gradually (1000.0 +/- 0.0% on day 7, 854.3 +/- 132.5% on day 14, and 302.6 +/- 92.3% on day 28). On day 28 after axotomy, JOR occurrence and the relative JOR threshold had almost returned to those of sham rats. These findings suggest that Slitl and Robo2 are involved in the regeneration and functional recovery of the axotomized IAN.
dc.description.sponsorshipNamik Kemal University, Scientific Research Projects CommitteeNamik Kemal University [NKU-BAP.00.20.AR.12.10]
dc.description.sponsorshipThis study was supported by Namik Kemal University, Scientific Research Projects Committee (Project No. NKU-BAP.00.20.AR.12.10).
dc.identifier.doi10.1016/j.ijom.2014.09.022
dc.identifier.endpage527
dc.identifier.issn0901-5027
dc.identifier.issn1399-0020
dc.identifier.issue4en_US
dc.identifier.pmid25457824
dc.identifier.scopus2-s2.0-84924536636
dc.identifier.scopusqualityQ1
dc.identifier.startpage518
dc.identifier.urihttps://doi.org/10.1016/j.ijom.2014.09.022
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5158
dc.identifier.volume44
dc.identifier.wosWOS:000351966100017
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorCeber, Mehmet
dc.institutionauthorŞener, Ümit
dc.institutionauthorYüksek, A.
dc.institutionauthorDurak, M. A.
dc.institutionauthorTülübaş, Feti
dc.language.isoen
dc.publisherChurchill Livingstone
dc.relation.ispartofInternational Journal of Oral and Maxillofacial Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSlit1
dc.subjectRobo2
dc.subjectinferior alveolar nerve
dc.subjectaxotomy
dc.subjectnerve regeneration
dc.subjectjaw opening reflex
dc.subjectDorsal-Root Ganglion
dc.subjectSensory Neurons
dc.subjectDynamic Changes
dc.subjectMessenger-Rna
dc.subjectProtein
dc.subjectRegeneration
dc.subjectRoundabout
dc.subjectRepellent
dc.subjectGuidance
dc.subjectMidline
dc.titleChanges in expression of Slit1 and its receptor Robo2 in trigeminal ganglion and inferior alveolar nerve following inferior alveolar nerve axotomy in adult rats: a pilot study
dc.typeArticle

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