Protective Effects of Idebenone against Sepsis Induced Acute Lung Damage

Basit Öğe Kaydı
dc.authorid0000-0002-8284-8317
dc.authorid0000-0002-3365-7741
dc.authorscopusid23392019500
dc.authorscopusid57117956600
dc.authorscopusid56779839000
dc.authorscopusid55203028300
dc.authorscopusid57222464081
dc.authorscopusid55770146200
dc.authorscopusid55367802000
dc.authorwosidDincer, Busra/AAD-7462-2021
dc.contributor.authorAkpınar, Erol
dc.contributor.authorKutlu, Zerrin
dc.contributor.authorKöse, Duygu
dc.contributor.authorAydın, Pelin
dc.contributor.authorTavacı, Taha
dc.contributor.authorBayraktutan, Zafer
dc.contributor.authorDinçer, Büşra
dc.contributor.authorYüksel, Tuğba Nurcan
dc.date.accessioned2022-05-11T14:41:12Z
dc.date.available2022-05-11T14:41:12Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.description.abstractBackground/Aims Sepsis is an uncontrolled systemic infection, withcomplex pathophysiology that may result in acute lung organ damage and cause multiple organ failure. Although much research has been conducted to illuminate sepsis's complex pathophysiology, sepsis treatment protocols are limited, and sepsis remains an important cause of mortality andmorbidity in intensive care units.Various studies have shown that idebenone (IDE) possesses strong antioxidant properties, which inhibit lipid peroxidation and protect cells from oxidative damage. The present study aimed to evaluate the protective effects of IDE against lung injury in a cecal ligation and puncture (CLP)-induced sepsis rat model. Methods Male albino Wistar rats were used. The animals were divided into a healthy control (no treatment), CLP, IDE control (200 mg/kg), and CLP + IDE subgroups (50 mg/kg, 100 mg/kg, and 200 mg/kg), with nine rats in each group.IDE was administered 1 h after CLP induction.To evaluate the protective effects of IDE, lung tissues were collected 16 h after sepsis for biochemical, immunohistochemical staining, and histopathological examination. Results IDE significantly ameliorated sepsis-induced disturbances in oxidative stress-related factors, with its effects increasing in accordance with the dose.IDE also abolished histopathological changes in lung tissues associated with CLP.Furthermore, interleukin 1 beta (IL-1 beta)and tumor necrosis factor-alpha (TNF-alpha) immunopositivity markedly decreased in the septic rats following IDE treatment. Conclusions IDE largely mitigated the inflammatory response in sepsis-induced lung injury by decreasing free radicals and preventing lipid peroxidation. The results suggest that IDE may represent a potential novel therapeutic drug for sepsis treatment.
dc.identifier.doi10.1080/08941939.2021.1898063
dc.identifier.endpage568
dc.identifier.issn0894-1939
dc.identifier.issn1521-0553
dc.identifier.issue3en_US
dc.identifier.pmid33722148
dc.identifier.scopus2-s2.0-85102770074
dc.identifier.scopusqualityQ2
dc.identifier.startpage560
dc.identifier.urihttps://doi.org/10.1080/08941939.2021.1898063
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9107
dc.identifier.volume35
dc.identifier.wosWOS:000629409600001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYüksel, Tuğba Nurcan
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofJournal of Investigative Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectIdebenone
dc.subjectsepsis
dc.subjectantioxidantlung injuryrat
dc.subjectoxidative stress
dc.titleProtective Effects of Idebenone against Sepsis Induced Acute Lung Damage
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
9107.pdf
Boyut:
2.88 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Tıp Fakültesi Koleksiyonu