Urinary excretion of pentraxin-3 correlates with the presence of renal scar following acute pyelonephritis in children

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dc.authorid0000-0001-5080-3192
dc.authorid0000-0001-9415-1640
dc.authorid0000-0001-6277-1458
dc.authorscopusid55579588300
dc.authorscopusid8514659100
dc.authorscopusid12797821400
dc.authorscopusid36002733700
dc.authorscopusid13103361300
dc.authorwosidEnli, Yaşar/AAB-9154-2020
dc.authorwosidBecerir, Tülay/AAO-9887-2020
dc.authorwosidYUKSEL, SELCUK/C-5473-2015
dc.contributor.authorBecerir, Tülay
dc.contributor.authorYüksel, Selcuk
dc.contributor.authorEvrengül, Havva
dc.contributor.authorErgin, Ahmet
dc.contributor.authorEnli, Yaşar
dc.date.accessioned2022-05-11T14:37:14Z
dc.date.available2022-05-11T14:37:14Z
dc.date.issued2019
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractPurpose Acute pyelonephritis is associated with considerable morbidity and potential for renal scarring. Pentraxin3 (PTX3) is a recently discovered mediator of inflammation. The objective of this study was to investigate the changes in serum and urine PTX3 levels in children who had a history of pyelonephritis and were diagnosed with renal parenchymal scar (RPS) and/or vesicoureteral reflux (VUR). Methods The study included 88 children (31 males, 57 females) aged between 3months and 18years. The children included in the study were divided into four groups: VUR with RPS (Group 1), RPS without VUR (Group 2), VUR without RPS (Group 3), and healthy children without a history of hydronephrosis or UTI history (Group 4). After the initial evaluation, the participants were further divided into two more groups and re-evaluated: Children with RPS (Group 1+2), children without RPS (Group 3+4), children with VUR (Group 1+3), and children without VUR (Group 2+4). Results We found that urine pentraxin 3 (uPTX3) and uPTX3/Creatinine levels were significantly higher in the groups with renal scar with or without VUR than the ones without RPS [mean uPTX3, 3.5pg/ml (min-max 0.0022-12.3668) vs. 2.2pg/ml (min-max 0.0022-18.5868) and uPTX3/creatinine, 10.5pg/mg (min-max 0.0035-51.1) vs. 5.8pg/mg (min-max 0.0004-78.7), p<0.01]. uPTX3 levels were not different among the groups with and without VUR. In addition, serum PTX3 levels were not different among the groups. Conclusions We showed that urinary PTX3 increased only in patients with scarred kidneys. These results might be helpful to predict RPS due to past pyelonephritis.
dc.description.sponsorshipPamukkale University Research FundPamukkale University [2015HZL007]
dc.description.sponsorshipThis research has been supported by Pamukkale University Research Fund (Number 2015HZL007).
dc.identifier.doi10.1007/s11255-019-02102-8
dc.identifier.endpage577
dc.identifier.issn0301-1623
dc.identifier.issn1573-2584
dc.identifier.issue4en_US
dc.identifier.pmid30796728
dc.identifier.scopus2-s2.0-85061988993
dc.identifier.scopusqualityQ2
dc.identifier.startpage571
dc.identifier.urihttps://doi.org/10.1007/s11255-019-02102-8
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8631
dc.identifier.volume51
dc.identifier.wosWOS:000464869600002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBecerir, Tülay
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofInternational Urology and Nephrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectChildren
dc.subjectPentraxin 3
dc.subjectRenal scar
dc.subjectVesicoureteral reflux
dc.subjectVesicoureteral Reflux
dc.subjectInnate Immunity
dc.subjectPtx3
dc.subjectInterleukin-8
dc.subjectImmunology
dc.subjectExpression
dc.titleUrinary excretion of pentraxin-3 correlates with the presence of renal scar following acute pyelonephritis in children
dc.typeArticle

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