Surgical management of stage-2 medication-related osteonecrosis of the jaw with transplantation of human amniotic membrane: Preliminary results

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dc.authorscopusid57679570300
dc.authorscopusid36674961600
dc.authorscopusid25421095500
dc.authorscopusid8915634200
dc.contributor.authorÇanakçı, F.Gülfeşan
dc.contributor.authorEr, Nilay
dc.contributor.authorDuygu, Gonca
dc.contributor.authorVarol, G.Füsun
dc.date.accessioned2023-04-20T08:04:16Z
dc.date.available2023-04-20T08:04:16Z
dc.date.issued2022
dc.departmentFakülteler, Diş Hekimliği Fakültesi, Klinik Bilimler Bölümü
dc.description.abstractMedication-related osteonecrosis of the jaw (MRONJ) is a drug adverse reaction. Seven osteonecrosis areas in 5 cases were treated with stage-2 MRONJ using human amniotic membrane (HAM) transplantation after sequestrectomy. Patients were evaluated in terms of infection (pain, erythema, and pus), mucosal coverage, and pain at 1, 2, 4, 8, and 12 weeks. Patients who showed improvement (total mucosal coverage, no sign of infection and pain) at the end of 12 weeks were followed up every 8 weeks. Also, radiographic examinations (panoramic radiography at every 8 weeks, cone-beam computed tomography at every 6 months) were performed to evaluate bone destruction. Complete mucosal closure was achieved in 6 necrosis sites. In only 1 patient, mucosal coverage was not achieved. No pain and infection relapse were observed during the follow-ups. HAM might be an effective material in terms of soft tissue healing and elimination of pain and infection for stage-2 MRONJ. Clinical Trials Registration Number: NCT04967963 © 2021
dc.description.sponsorshipTrakya Üniversitesi: 2018/275
dc.description.sponsorshipThis study was supported financially by Trakya University , Scientific Research Project Department ( 2018/275 ).
dc.identifier.doi10.1016/j.jormas.2021.09.011
dc.identifier.endpagee31
dc.identifier.issn2468-7855
dc.identifier.issue3en_US
dc.identifier.pmid34563730
dc.identifier.scopus2-s2.0-85129908450
dc.identifier.scopusqualityQ2
dc.identifier.startpagee28
dc.identifier.urihttps://doi.org/10.1016/j.jormas.2021.09.011
dc.identifier.urihttps://hdl.handle.net/20.500.11776/11066
dc.identifier.volume123
dc.identifier.wosWOS:000883690500005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDuygu, Gonca
dc.language.isoen
dc.publisherElsevier Masson s.r.l.
dc.relation.ispartofJournal of Stomatology, Oral and Maxillofacial Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAmniotic membrane
dc.subjectBisphosphonates
dc.subjectMedication-related osteonecrosis of the jaw
dc.subjectMRONJ
dc.subjectMucosal coverage
dc.subjectbone density conservation agent
dc.subjectamnion
dc.subjectcase report
dc.subjecthuman
dc.subjectjaw osteonecrosis
dc.subjectpain
dc.subjectpanoramic radiography
dc.subjectAmnion
dc.subjectBisphosphonate-Associated Osteonecrosis of the Jaw
dc.subjectBone Density Conservation Agents
dc.subjectHumans
dc.subjectPain
dc.subjectRadiography, Panoramic
dc.titleSurgical management of stage-2 medication-related osteonecrosis of the jaw with transplantation of human amniotic membrane: Preliminary results
dc.typeArticle

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