Nasal mucociliary clearance in obstructive sleep apnea syndrome patients

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dc.authorid0000-0003-3307-085X
dc.authorscopusid15055538600
dc.authorscopusid26648338400
dc.authorscopusid55078843000
dc.authorscopusid14047809600
dc.authorscopusid56382793200
dc.authorscopusid56197552400
dc.authorscopusid56197872500
dc.authorwosidCiftci, Zafer/AAW-9972-2021
dc.contributor.authorDeniz, Mahmut
dc.contributor.authorGültekin, Erdoğan
dc.contributor.authorÇiftçi, Zafer
dc.contributor.authorAlp, Recep
dc.contributor.authorÖzdemir, Damla Nihan
dc.contributor.authorIşık, Aklime
dc.contributor.authorDemirel, Oral Burak
dc.date.accessioned2022-05-11T14:12:48Z
dc.date.available2022-05-11T14:12:48Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kulak Burun ve Boğaz Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractBackground: The main objective of this study was to investigate the correlation between the level of mucociliary dysfunction and severity of obstructive sleep apnea syndrome (OSAS). The effect of smoking in OSAS patients on mucociliary dysfunction was also assessed. Methods: It is a descriptive study that compares variables between groups (univariate analysis). In this clinical trial 122 patients with varying degrees of OSAS and 49 healthy volunteers were included (n = 171). Patients were divided into three groups as having mild, moderate, and severe OSAS, according to their apnea hypopnea index (AHI) values. (AHI values are typically categorized as 5-15/hr, mild OSAS; 15-30/hr, moderate OSAS; and >30/hr, severe OSAS.) The control group was comprised of healthy subjects. Each group was divided into smoking and nonsmoking subgroups. The mucociliary rates of the subjects were measured using the saccharin test. Statistical analysis was performed with the GraphPad Prism Version 3 pocket program. Results: Mild and moderate OSAS groups showed similar results with control group (p = 0.869), but severe OSAS patients showed a statistically significant difference with control group (Kruskal-Wallis [KW] = 32.28; p = 0.0032 and p < 0.05). Although in the moderate OSAS group the mucociliary clearance rates showed a tendency to decrease, this decrease was not significant (p = 0.453). A statistically significant difference was observed between smokers and nonsmokers in terms of mucociliary clearance times in all groups (KW = 18.24; p = 0.001). Conclusion: The nasal mucociliary system is significantly deteriorated in severe OSAS patients and they should be meticulously observed to prevent sinonasal infections. Measures to enhance mucociliary activity in these patients should be taken. Smoking, a well-known inhibitor of mucociliary activity, also has a negative impact on the mucociliary function of OSAS patients and quitting smoking would be of benefit for these patients.
dc.identifier.doi10.2500/ajra.2014.28.4094
dc.identifier.endpageE180
dc.identifier.issn1945-8924
dc.identifier.issn1945-8932
dc.identifier.issue5en_US
dc.identifier.pmid25198014
dc.identifier.scopus2-s2.0-84907918306
dc.identifier.scopusqualityQ1
dc.identifier.startpageE178
dc.identifier.urihttps://doi.org/10.2500/ajra.2014.28.4094
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5678
dc.identifier.volume28
dc.identifier.wosWOS:000342748300002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDeniz, Mahmut
dc.institutionauthorGültekin, Erdoğan
dc.institutionauthorÇiftçi, Zafer
dc.institutionauthorAlp, Recep
dc.institutionauthorÖzdemir, Damla Nihan
dc.institutionauthorIşık, Aklime
dc.institutionauthorDemirel, Oral Burak
dc.language.isoen
dc.publisherOcean Side Publications Inc
dc.relation.ispartofAmerican Journal of Rhinology & Allergy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSurgery
dc.subjectAdults
dc.subjectNcpap
dc.subjectNose
dc.subjectEpithelium
dc.titleNasal mucociliary clearance in obstructive sleep apnea syndrome patients
dc.typeArticle

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