Comparative proteogenomic analysis of right-sided colon cancer, left-sided colon cancer and rectal cancer reveals distinct mutational profiles

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dc.authorid0000-0002-2661-5746
dc.authorid0000-0001-5495-7754
dc.authorid0000-0001-5495-7754
dc.authorscopusid57197859481
dc.authorscopusid57210013495
dc.authorscopusid57197856997
dc.authorscopusid56038664700
dc.authorscopusid57205178810
dc.authorscopusid57205179724
dc.authorscopusid57205182329
dc.authorwosidel-rayes, bassel/ABD-2901-2021
dc.authorwosidErdoğan, Cihat/A-4856-2018
dc.authorwosidErdoğan, Cihat/E-4681-2019
dc.authorwosidMasood, Ashiq/V-6588-2019
dc.authorwosidKhaliq, Ateeq/AAL-3124-2021
dc.authorwosidDiri, Banu/AAA-1020-2021
dc.contributor.authorImperial, Robin
dc.contributor.authorAhmed, Zaheer
dc.contributor.authorToor, Omer M.
dc.contributor.authorErdoğan, Cihat
dc.contributor.authorKhaliq, Ateeq
dc.contributor.authorCase, Paul
dc.contributor.authorMasood, Ashiq
dc.date.accessioned2022-05-11T14:15:52Z
dc.date.available2022-05-11T14:15:52Z
dc.date.issued2018
dc.departmentFakülteler, Çorlu Mühendislik Fakültesi, Bilgisayar Mühendisliği Bölümü
dc.description.abstractRight-sided colon cancer (RCC) has worse prognosis compared to left-sided colon cancer (LCC) and rectal cancer. The reason for this difference in outcomes is not well understood. We performed comparative somatic and proteomic analyses of RCC, LCC and rectal cancers to understand the unique molecular features of each tumor sub-types. Utilizing a novel in silico clonal evolution algorithm, we identified common tumor-initiating events involving APC, KRAS and TP53 genes in RCC, LCC and rectal cancers. However, the individual role-played by each event, their order in tumor development and selection of downstream somatic alterations were distinct in all three anatomical locations. Some similarities were noted between LCC and rectal cancer. Hotspot mutation analysis identified a nonsense mutation, APC R1450* specific to RCC. In addition, we discovered new significantly mutated genes at each tumor location, Further in silico proteomic analysis, developed by our group, found distinct central or hub proteins with unique interactomes among each location. Our study revealed significant differences between RCC, LCC and rectal cancers not only at somatic but also at proteomic level that may have therapeutic relevance in these highly complex and heterogeneous tumors.
dc.description.sponsorshipMerit Review Award, Medical Research Service, Department of Veterans AffairsUS Department of Veterans Affairs [I01 BX000545]; Veterans AffairsUS Department of Veterans Affairs [I01BX000545] Funding Source: NIH RePORTER
dc.description.sponsorshipPart of A. H.'s time was supported by a Merit Review Award (I01 BX000545), Medical Research Service, Department of Veterans Affairs.
dc.identifier.doi10.1186/s12943-018-0923-9
dc.identifier.issn1476-4598
dc.identifier.pmid30577807
dc.identifier.scopus2-s2.0-85058907228
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1186/s12943-018-0923-9
dc.identifier.urihttps://hdl.handle.net/20.500.11776/6105
dc.identifier.volume17
dc.identifier.wosWOS:000454253100001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorErdoğan, Cihat
dc.language.isoen
dc.publisherBmc
dc.relation.ispartofMolecular Cancer
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectRight-sided colon cancer
dc.subjectLeft-sided colon cancer
dc.subjectRectal cancers
dc.subjectClonal evolution
dc.subjectProteomics
dc.subjectHotspot mutations
dc.titleComparative proteogenomic analysis of right-sided colon cancer, left-sided colon cancer and rectal cancer reveals distinct mutational profiles
dc.typeArticle

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