Immunologic changes during desensitization with cow's milk: How it differs from natural tolerance or nonallergic state?

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dc.authorscopusid37092966400
dc.authorscopusid6505770201
dc.authorscopusid54889084200
dc.authorscopusid7006914574
dc.authorscopusid6603599022
dc.authorscopusid9036191300
dc.authorscopusid7004014994
dc.contributor.authorGünaydın, Nursen Ciğerci
dc.contributor.authorAzarsız, E.
dc.contributor.authorSüslüer, S.Y.
dc.contributor.authorKütükçüler, N.
dc.contributor.authorGündüz, C.
dc.contributor.authorGülen, Figen
dc.contributor.authorDemir, Esen
dc.date.accessioned2023-04-20T08:04:17Z
dc.date.available2023-04-20T08:04:17Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground: Oral immunotherapy (OIT) is a novel allergen-specific treatment for food allergies. Objective: To investigate the effect of OIT on blocking antibodies, T cell regulation, and cytokine response during immunoglobulin (Ig)E-mediated cow's milk allergy (CMA) treatment. Methods: A total of 59 children with IgE-mediated CMA who were followed in pediatric allergy outpatient clinic and 18 healthy children were included. The children were evaluated in the following 4 groups: OIT group, elimination group (patients receiving dairy elimination diet), tolerance group (patients who developed tolerance), and healthy control group. Milk-specific IgE, IgG4, and IgA levels, cow's milk induration diameters in skin prick test, CD4 + CD25 + FoxP3 + Treg cell percentages, messenger RNA (mRNA) expressions, and interleukin (IL)-10, transforming growth factor-beta (TGF-?), IL-2, IL-4, and IL-13 cytokine levels were compared between the groups. Results: The mean age of the patients was 42.6 ± 39 (6-201) months, and 63.6% (n = 49) of the patients were girls. We observed an increase in total IgE levels (P = .02), a decrease in cow's milk sIgE (P = .08, NS), and an increase in cow's milk component (?-lactoglobulin and casein) specific IgA (P < .05) and IgG4 (P < .001) levels at 2 months after the maintenance phase of OIT. In addition, the immune response after OIT treatment, which had a 100% clinical success rate, was notable for similar CD4 + CD25 + FoxP3 + cell percentages (P = .8), and increased IL-10 (P = .04) levels and increased but statistically nonsignificant TGF-? levels (P = .17) compared with those before treatment. FoxP3 mRNA expression was similar to that of patients who developed natural tolerance. Pretreatment and post-treatment FoxP3 mRNA-FoxP3 flow cytometric expressions were positively correlated with TGF-? concentrations in the OIT group. Conclusion: A successful immune response to OIT was found, possibly through the blockage of IgE-mediated allergen presentation by blocking antibodies, marked IL-10 cytokine response, and TGF-? response. FoxP3 mRNA expression was similar to the natural tolerance mechanism, but more studies are needed. © 2022 American College of Allergy, Asthma & Immunology
dc.description.sponsorshipEge Üniversitesi: 2014-TIP-011
dc.description.sponsorshipFunding: This study was supported by Ege University Scientific Research Projects Coordination Unit with the project number 2014-TIP-011. This study was applied in Ege University Faculty of Medicine.
dc.description.sponsorshipFunding: This study was supported by Ege University Scientific Research Projects Coordination Unit with the project number 2014-TIP-011. This study was applied in Ege University Faculty of Medicine.
dc.identifier.doi10.1016/j.anai.2022.07.022
dc.identifier.issn1081-1206
dc.identifier.pmid35914664
dc.identifier.scopus2-s2.0-85137035571
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.anai.2022.07.022
dc.identifier.urihttps://hdl.handle.net/20.500.11776/11068
dc.identifier.wosWOS:000894758900025
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGünaydın, Nurşen Ciğerci
dc.language.isoen
dc.publisherAmerican College of Allergy, Asthma and Immunology
dc.relation.ispartofAnnals of Allergy, Asthma and Immunology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.titleImmunologic changes during desensitization with cow's milk: How it differs from natural tolerance or nonallergic state?
dc.typeArticle

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