Development and validation of a modified quick SOFA scale for risk assessment in sepsis syndrome

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dc.authorid0000-0002-9033-4236
dc.authorid0000-0003-3790-3070
dc.authorid0000-0003-1867-9018
dc.authorid0000-0002-3294-014X
dc.authorid0000-0002-6760-2052
dc.authorid0000-0001-8027-1991
dc.authorid0000-0003-1514-1685
dc.authorscopusid35764273000
dc.authorscopusid23060531400
dc.authorscopusid10340240700
dc.authorscopusid24069724000
dc.authorscopusid55865109300
dc.authorscopusid6505508467
dc.authorscopusid6505778155
dc.authorwosidCag, Yasemin/S-7343-2016
dc.authorwosidErdogan, Haluk/O-2247-2015
dc.authorwosidÖnal, Uğur/AAH-6639-2021
dc.authorwosidEser, Fatma/AAO-3498-2021
dc.authorwosidSipahi, Oguz Resat/AAR-2916-2020
dc.authorwosidAk, Öznur/ABB-7066-2020
dc.authorwosidKarasu, Derya/F-1579-2017
dc.contributor.authorÇağ, Yasemin
dc.contributor.authorKarabay, Oğuz
dc.contributor.authorSipahi, Oguz Resat
dc.contributor.authorAksoy, Firdevs
dc.contributor.authorDurmuş, Gül
dc.contributor.authorBatırel, Ayşe
dc.contributor.authorVahaboglu, Haluk
dc.contributor.authorErdem, İlknur
dc.date.accessioned2022-05-11T14:37:23Z
dc.date.available2022-05-11T14:37:23Z
dc.date.issued2018
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları Ana Bilim Dalı
dc.description.abstractSepsis is a severe clinical syndrome owing to its high mortality. Quick Sequential Organ Failure Assessment (qSOFA) score has been proposed for the prediction of fatal outcomes in sepsis syndrome in emergency departments. Due to the low predictive performance of the qSOFA score, we propose a modification to the score by adding age. We conducted a multicenter, retrospective cohort study among regional referral centers from various regions of the country. Participants recruited data of patients admitted to emergency departments and obtained a diagnosis of sepsis syndrome. Crude in-hospital mortality was the primary endpoint. A generalized mixed-effects model with random intercepts produced estimates for adverse outcomes. Model-based recursive partitioning demonstrated the effects and thresholds of significant covariates. Scores were internally validated. The H measure compared performances of scores. A total of 580 patients from 22 centers were included for further analysis. Stages of sepsis, age, time to antibiotics, and administration of carbapenem for empirical treatment were entered the final model. Among these, severe sepsis (OR, 4.40; CIs, 2.35-8.21), septic shock (OR, 8.78; CIs, 4.37-17.66), age (OR, 1.03; CIs, 1.02-1.05) and time to antibiotics (OR, 1.05; CIs, 1.01-1.10) were significantly associated with fatal outcomes. A decision tree demonstrated the thresholds for age. We modified the quick Sequential Organ Failure Assessment (mod-qSOFA) score by adding age (> 50 years old = one point) and compared this to the conventional score. H-measures for qSOFA and mod-qSOFA were found to be 0.11 and 0.14, respectively, whereas AUCs of both scores were 0.64. We propose the use of the modified qSOFA score for early risk assessment among sepsis patients for improved triage and management of this fatal syndrome.
dc.identifier.doi10.1371/journal.pone.0204608
dc.identifier.issn1932-6203
dc.identifier.issue9en_US
dc.identifier.pmid30256855
dc.identifier.scopus2-s2.0-85054061716
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0204608
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8674
dc.identifier.volume13
dc.identifier.wosWOS:000446000200057
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorErdem, İlknur
dc.language.isoen
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectInflammatory Response Syndrome
dc.subjectPathogens
dc.subjectCriteria
dc.subjectEpidemiology
dc.subjectDefinitions
dc.titleDevelopment and validation of a modified quick SOFA scale for risk assessment in sepsis syndrome
dc.typeArticle

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