The Determination of Single and Mixture Toxicity at High Concentrations of Some Acidic Pharmaceuticals via Aliivibrio fischeri

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dc.authorid0000-0002-4439-4422
dc.authorscopusid26434143900
dc.authorscopusid6603559061
dc.authorscopusid7801446577
dc.authorwosidDokmeci, Ayse/H-7591-2012
dc.contributor.authorDökmeci, Ayşe Handan
dc.contributor.authorDökmeci, İsmet
dc.contributor.authorİbar, Hilmi
dc.date.accessioned2022-05-11T14:48:32Z
dc.date.available2022-05-11T14:48:32Z
dc.date.issued2014
dc.departmentYüksekokullar, Sağlık Yüksekokulu, Acil Yardım ve Afet Yönetimi Bölümü
dc.description.abstractPharmaceutical and Personal Care Products (PPCPs) may cause serious and significant environmental pollution. Environmental analyses have detected pharmaceuticals in addition to conventional chemical pollutants. In our study, the acute toxicity of ibuprofen, naproxen, diclofenac, salicylic acid and substances that are mixtures themselves (INDS) on Aliivibrio fischeri bacterium were assessed with the use of ToxAlert (R). The selected materials are acidic in nature, highly polarized and widely sold over-the-counter analgesics. Dose-response curves were drawn, and linear regression analyses and probit analyses determined their 50 %-effective concentrations (EC50). The pharmaceuticals alone are unlikely to have acute impacts in aquatic environments. However, when evaluated in combination with A. fischeri bacterium, the acute toxicity of the INDS mixture was EC50 7.09 +/- 5.1 mg/L and the acute toxicity of TUs was 14.10, which indicates their very toxic quality for organisms. Since the target components do not exist in isolation, we should primarily consider the toxicity of the mixture only at high concentrations.
dc.description.sponsorshipTrakya University Scientific Research ProjectTrakya University [TUBAP-120]
dc.description.sponsorshipThis study was supported by Trakya University Scientific Research Project TUBAP-120. The authors are grateful to the TUBITAK Marmara Research Center for conducting the toxicity measurements. An initial version of this paper was presented at the 8th International Conference of the EWRA in Porto, Portugal, June 26-29, 2013.
dc.identifier.doi10.1007/s40710-014-0009-7
dc.identifier.endpage103
dc.identifier.issn2198-7491
dc.identifier.issn2198-7505
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84950349938
dc.identifier.scopusqualityQ1
dc.identifier.startpage95
dc.identifier.urihttps://doi.org/10.1007/s40710-014-0009-7
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10654
dc.identifier.volume1
dc.identifier.wosWOS:000434725600001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorDökmeci, Ayşe Handan
dc.language.isoen
dc.publisherSpringer International Publishing Ag
dc.relation.ispartofEnvironmental Processes-An International Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectIbuprofen
dc.subjectNaproxen
dc.subjectDiclofenac
dc.subjectSalicylic acid
dc.subjectMixture toxicity
dc.subjectAliivibrio fischeri
dc.titleThe Determination of Single and Mixture Toxicity at High Concentrations of Some Acidic Pharmaceuticals via Aliivibrio fischeri
dc.typeArticle

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