Anti-Apoptotic and Anti-Oxidant Effects of Caffeic Acid Phenethyl Ester on Cadmium-Induced Testicular Toxicity in Rats

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dc.authorscopusid36023238400
dc.authorscopusid7006356462
dc.authorscopusid24436194200
dc.authorscopusid56755425900
dc.authorscopusid56659422100
dc.authorscopusid56912006500
dc.authorscopusid36866111300
dc.authorwosidAktas, Cevat/D-8468-2011
dc.contributor.authorErboğa, Mustafa
dc.contributor.authorKanter, Mehmet
dc.contributor.authorAktaş, Cevat
dc.contributor.authorDönmez, Yeliz Bozdemir
dc.contributor.authorErboğa, Zeynep Fidanol
dc.contributor.authorAktaş, Emel
dc.contributor.authorGürel, Ahmet
dc.date.accessioned2022-05-11T14:14:06Z
dc.date.available2022-05-11T14:14:06Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractCadmium (Cd) is a serious environmental and occupational contaminant and may represent a serious health hazard to humans and other animals. Cd is reported to induce the generation of reactive oxygen species, and induces testicular damage in many species of animals. The goal of our study was to examine the anti-apoptotic and anti-oxidant effects of caffeic acid phenethyl ester (CAPE) on Cd-induced oxidative stress, apoptosis, and testicular injury in rats. A total of 40 male Wistar albino rats were divided into four groups: control, CAPE alone, Cd-treated, and Cd-treated with CAPE; each group consisted of 10 animals. To induce toxicity, Cd (1 mg/kg body weight) was dissolved in normal saline and subcutaneously injected into rats for 30 days. The rats in CAPE-treated group were given a daily dose of 10 mu mol/kg body weight of CAPE by using intraperitoneal injection. This application was continued daily for a total of 30 days. To date, no examinations of the anti-apoptotic and anti-oxidant properties of CAPE on Cd-induced apoptosis, oxidative damage, and testicular injury in rat testes have been reported. CAPE-treated animals showed an improved histological appearance and serum testosterone levels in Cd-treated group. Our data indicate a significant reduction in the number of apoptotic cells in testis tissues of the Cd-treated group with CAPE treatment. Moreover, CAPE significantly suppressed lipid peroxidation, compensated deficits in the anti-oxidant defenses in testes tissue resulted from Cd administration. These findings suggest that the protective potential of CAPE in Cd toxicity might be due to its anti-oxidant and anti-apoptotic properties, which could be useful for achieving optimum effects in Cd-induced testicular injury.
dc.description.sponsorshipNamik Kemal University Research Center, Tekirdag, TurkeyNamik Kemal University [NKUBAP.00.20.AR.14.13]
dc.description.sponsorshipThis study was funded under Project NKUBAP.00.20.AR.14.13 by the Namik Kemal University Research Center, Tekirdag, Turkey.
dc.identifier.doi10.1007/s12011-015-0509-y
dc.identifier.endpage184
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue1en_US
dc.identifier.pmid26424218
dc.identifier.scopus2-s2.0-84944699167
dc.identifier.scopusqualityQ1
dc.identifier.startpage176
dc.identifier.urihttps://doi.org/10.1007/s12011-015-0509-y
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5780
dc.identifier.volume171
dc.identifier.wosWOS:000374390100024
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorErboğa, Mustafa
dc.institutionauthorDönmez, Yeliz Bozdemir
dc.institutionauthorErboğa, Zeynep Fidanol
dc.institutionauthorAktaş, Emel
dc.institutionauthorGürel, Ahmet
dc.language.isoen
dc.publisherHumana Press Inc
dc.relation.ispartofBiological Trace Element Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCadmium
dc.subjectCAPE
dc.subjectTesticular toxicity
dc.subjectApoptosis
dc.subjectOxidative stress
dc.subjectTestosterone
dc.subjectInduced Oxidative Stress
dc.subjectGerm-Cell Apoptosis
dc.subjectProtective Role
dc.subjectInjury
dc.subjectTestes
dc.subjectDamage
dc.subjectMice
dc.subjectCape
dc.subjectMetallothionein
dc.subjectCarcinogenesis
dc.titleAnti-Apoptotic and Anti-Oxidant Effects of Caffeic Acid Phenethyl Ester on Cadmium-Induced Testicular Toxicity in Rats
dc.typeArticle

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