Novel Approach to Investigate the Effect of High-Dose Methylprednisolone on Erythrocyte Morphology: White Light Diffraction Microscopy

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dc.authoridALTUNAN, BENGU/0000-0001-6034-8808
dc.contributor.authorDeniz, Cigdem
dc.contributor.authorKocahan, Ozlem
dc.contributor.authorAltunan, Bengu
dc.contributor.authorUnal, Aysun
dc.date.accessioned2024-10-29T17:59:03Z
dc.date.available2024-10-29T17:59:03Z
dc.date.issued2023
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractThe present study focuses on quantitative phase imaging of erythrocytes with the aim to evaluate the effects of high-dose methylprednisolone (HDMP) on erythrocytes in vivo under physiological conditions in human blood samples. Samples from ten patients, prescribed to be treated with 1000 mg/day intravenous methylprednisolone for 5 days, were analyzed by white light diffraction phase microscopy (WDPM) for quantitative imaging. WDPM, an optical measurement technique, enables single shot measurement and low speckle noise using white light. Quantitative phase imaging performed with this experimental setup allowed the determination of erythrocyte morphology with 9 different parameters. In vivo quantitative analysis of erythrocytes by WDPM, which is a simple and reliable method, shows that HDMP treatment has no significant effect on erythrocyte morphology. With the developing technology, interdisciplinary studies on individuals under treatment should play an important role in elucidating the interaction between steroids and erythrocytes.
dc.description.sponsorshipTurkish Scientific and Technical Research Council [122E201]
dc.description.sponsorshipThis work is supported by the Turkish Scientific and Technical Research Council. Grant number: 122E201.
dc.identifier.doi10.2478/msr-2023-0026
dc.identifier.endpage209
dc.identifier.issn1335-8871
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85175352874
dc.identifier.scopusqualityQ3
dc.identifier.startpage202
dc.identifier.urihttps://doi.org/10.2478/msr-2023-0026
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14609
dc.identifier.volume23
dc.identifier.wosWOS:001090197800002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSciendo
dc.relation.ispartofMeasurement Science Review
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectQuantitative phase imaging
dc.subjectmorphology
dc.subjecterythrocyte
dc.subjecthigh-dose methylprednisolone
dc.subjectwhite light diffraction phase microscopy
dc.subjectred blood cell
dc.titleNovel Approach to Investigate the Effect of High-Dose Methylprednisolone on Erythrocyte Morphology: White Light Diffraction Microscopy
dc.typeArticle

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