Elevated serum levels of procollagen C-proteinase enhancer-1 in patients with chronic kidney disease is associated with a declining glomerular filtration rate

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dc.authorid0000-0003-2520-6825
dc.authorscopusid8570900600
dc.authorscopusid23968920100
dc.authorscopusid57201255297
dc.authorscopusid57202336559
dc.authorscopusid57190404723
dc.authorscopusid6603926071
dc.authorwosidFidan, Cigdem/X-7070-2018
dc.authorwosidUlusoy, Sukru/AAL-9150-2021
dc.contributor.authorÖzkan, Gülsüm
dc.contributor.authorGüzel, Savaş
dc.contributor.authorAtar, Reşit Volkan
dc.contributor.authorFidan, Çiğdem
dc.contributor.authorKara, Sonat Pınar
dc.contributor.authorUlusoy, Şükrü
dc.date.accessioned2022-05-11T14:14:04Z
dc.date.available2022-05-11T14:14:04Z
dc.date.issued2019
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractBackground Procollagen C-proteinase enhancer-1 (PCPE-1) is a 55 kDa glycoprotein, which increases the activity of procollagen C-proteinases that break down C-terminal propeptides. Studies have shown that PCPE-1 is involved in the fibrotic process that occurs in various tissues and organs. Our review of the literature revealed no data concerning the relation between PCPE-1 and chronic kidney disease (CKD). The purpose of this study was to determine PCPE-1 levels in CKD. Methods One hundred thirty-one CKD patients and 34 healthy controls were included in our study. Demographic data were recorded, and routine biochemical tests were performed. Blood specimens were collected for PCPE-1 investigation. Demographic data, biochemical test results and PCPE-1 levels were compared between the control and patient groups. Parameters affecting PCPE-1 levels in our patient group were assessed. Results Procollagen C-proteinase enhancer-1 levels were significantly higher in our patient group compared to the control group. Parameters affecting PCPE-1 elevation in the patient group were identified as systolic blood pressure, blood urea nitrogen, phosphorus, haemoglobin, intact parathormone levels, glomerular filtration rate and body mass index. Conclusion We determined high PCPE-1 levels in CKD patients. PCPE-1 levels being negatively correlated with glomerular filtration rate suggests that PCPE-1 may be associated with progression in CKD patients.
dc.identifier.doi10.1111/nep.13521
dc.identifier.endpage942
dc.identifier.issn1320-5358
dc.identifier.issn1440-1797
dc.identifier.issue9en_US
dc.identifier.pmid30393914
dc.identifier.scopus2-s2.0-85065167382
dc.identifier.scopusqualityQ2
dc.identifier.startpage938
dc.identifier.urihttps://doi.org/10.1111/nep.13521
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5766
dc.identifier.volume24
dc.identifier.wosWOS:000481570500008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖzkan, Gülsüm
dc.institutionauthorGüzel, Savaş
dc.institutionauthorAtar, Reşit Volkan
dc.institutionauthorFidan, Çiğdem
dc.institutionauthorKara, Sonat Pınar
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofNephrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectprocollagen C-proteinase enhancer-1
dc.subjectchronic kidney disease
dc.subjectfibrosis
dc.subjectFibroblasts
dc.subjectManagement
dc.subjectCkd
dc.titleElevated serum levels of procollagen C-proteinase enhancer-1 in patients with chronic kidney disease is associated with a declining glomerular filtration rate
dc.typeArticle

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