Comparison of the acute alterations in serum bone turnover markers and bone mineral density among women with surgical menopause

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dc.authorscopusid54779279700
dc.authorscopusid6506061779
dc.authorscopusid23968920100
dc.authorscopusid13807496600
dc.authorscopusid42661653300
dc.authorscopusid14519117500
dc.authorscopusid41861073000
dc.contributor.authorBahar, Sengul
dc.contributor.authorAbalı, Remzi
dc.contributor.authorGüzel, Savaş
dc.contributor.authorBozkurt, Serpil
dc.contributor.authorGüzel, Eda Çelik
dc.contributor.authorAral, Hale
dc.contributor.authorBoran, Ahmet Birtan
dc.date.accessioned2022-05-11T14:14:02Z
dc.date.available2022-05-11T14:14:02Z
dc.date.issued2011
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractObjective: To determine the effect of a sudden decrease in estrogen levels via bilateral oophorectomy on serum turnover markers and to examine their correlation with bone mineral density (BMD). Study design: This study included 51 women who had regular menses preoperatively and underwent bilateral oophorectomy for benign reasons. These women did not have any systemic disease or drug use that would influence bone metabolism. For each woman, spine and femur BMD were measured preoperatively and sixth months after surgery. Serum C-terminal telopeptide (CTX) and bone alkaline phosphatase (BAP) were measured preoperatively and at the first and sixth months after surgery. Correlations between bone turnover markers and BMD were pre- and post-operatively analyzed. Results: The mean serum CTX and BAP concentrations at the first and sixth postoperative months were significantly higher compared to the preoperative measurements (p = 0.001). Spine BMD values at the sixth postoperative month was significantly lower compared to preoperative period (p = 0.0001). There was a significant negative correlation between spine BMD values and BAP levels both in the preoperative period and at the sixth postoperative month (r = -0.407, p = 0.001), whereas a significant positive correlation between serum CTX and BAP was noted at this time periods (r = 0.615, p < 0.001). Conclusions: The results of this study showed that serum BAP and CTX levels rapidly increase in women after bilateral oophorectomy. Therefore, these markers (especially BAP) could be useful in the evaluation of osteoporosis risk in the early period of surgical menopause. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
dc.identifier.doi10.1016/j.ejogrb.2011.06.033
dc.identifier.endpage197
dc.identifier.issn0301-2115
dc.identifier.issn1872-7654
dc.identifier.issue1en_US
dc.identifier.pmid21764505
dc.identifier.scopus2-s2.0-81855221947
dc.identifier.scopusqualityN/A
dc.identifier.startpage194
dc.identifier.urihttps://doi.org/10.1016/j.ejogrb.2011.06.033
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5751
dc.identifier.volume159
dc.identifier.wosWOS:000298202800039
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAbalı, Remzi
dc.institutionauthorGüzel, Savaş
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofEuropean Journal of Obstetrics & Gynecology and Reproductive Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSurgical menopause
dc.subjectBone turnover
dc.subjectSerum C-terminal telopeptide
dc.subjectBone mineral density
dc.subjectBone specific alkaline phosphatase
dc.subjectHormone Replacement Therapy
dc.subjectLoss Following Oophorectomy
dc.subjectX-Ray Absorptiometry
dc.subjectBiochemical Markers
dc.subjectAlkaline-Phosphatase
dc.subjectPostmenopausal Women
dc.subjectOsteoporosis
dc.subjectCollagen
dc.subjectFracture
dc.subjectOsteocalcin
dc.titleComparison of the acute alterations in serum bone turnover markers and bone mineral density among women with surgical menopause
dc.typeArticle

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